2-(Boc-amino)-5-bromopyridine CAS 159451-66-8
| CAS No. | 159451-66-8 |
| Molecular Formula | C10H15BrN2O2 |
| Molecular Weight | 275.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-(Boc-amino)-5-bromopyridine (CAS 159451-66-8), a certified reference material (molecular formula C10H15BrN2O2, MW 275.14 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Boc-amino)-5-bromopyridine (C10H15BrN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H15BrN2O2 |
| Molecular Weight | 275.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Boc Standards
- 4-Amino-6-(5-bromo-2-furyl)-1,6-dihydro-1,3,5-triazine-2-thiol (CAS 1142208-53-4)
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- 2-(3-Amino-4-bromo-1h-pyrazol-1-yl)-N-isopropyl-N-methylacetamide (CAS 1247402-64-7)
- 2-(3-Amino-4-bromo-1h-pyrazol-1-yl)-N-isopropylpropanamide (CAS 1247435-25-1)
- 3-(3-Amino-4-bromo-1h-pyrazol-1-yl)-N-isopropylpropanamide (CAS 1248321-76-7)
- 2-(3-Amino-4-bromo-1h-pyrazol-1-yl)-N-butylacetamide (CAS 1249223-96-8)
- 2-(3-Amino-4-bromo-1h-pyrazol-1-yl)-N-(tert-butyl)acetamide (CAS 1251372-44-7)
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Recommended Standards
- 9-(Bromomethyl)-9H-xanthene (CAS 1493431-21-2)
- 2-(2-Bromophenyl)-1-phenylethanone (CAS 16897-97-5)
- Methyl 4-bromo-5-isopentyl-1H-pyrazole-3-carboxylate (CAS 1491132-54-7)
- Ethyl 2-bromo-1-isopropyl-4-methyl-1H-imidazole-5-carboxylate (CAS 1708026-90-7)
- Dimenhydrinate (CAS 523-87-5)
- Vatred13 (CAS 4392-71-6)
- Methyl 1-(3-cyanopyrazin-2-yl)piperidine-4-carboxylate (CAS 1281293-76-2)
- 4-(Tert-butyl)-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)thiazol-2-amine (CAS 338409-42-0)
- 4-Hexylbicyclo[2.2.2]octan-1-ol (CAS 76921-52-3)
- (E)-N'-(4-(1H-imidazol-1-yl)benzylidene)thiophene-2-carbohydrazide (CAS 866009-62-3)
- 3-(3-Amino-5-methyl-1h-pyrazol-1-yl)tetrahydrothiophene 1,1-dioxide (CAS 1249584-33-5)
- (2R,3S,4R,5S,6S)-3-Methoxy-6-methyltetrahydro-2H-pyran-2,4,5-triol (CAS 1887228-22-9)
- 2-(Diethylamino)nicotinonitrile (CAS 17782-02-4)
- Tau Peptide (306-317) trifluoroacetate salt (CAS 1003007-59-7)
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