1-(2,6-Difluorobenzyl)-1H-pyrazol-4-ol CAS 1596958-21-2
| CAS No. | 1596958-21-2 |
| Molecular Formula | C10H8F2N2O |
| Molecular Weight | 210.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2,6-Difluorobenzyl)-1H-pyrazol-4-ol.
1-(2,6-Difluorobenzyl)-1H-pyrazol-4-ol (CAS 1596958-21-2), molecular formula C10H8F2N2O and molecular weight 210.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(2,6-Difluorobenzyl)-1H-pyrazol-4-ol (C10H8F2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8F2N2O |
| Molecular Weight | 210.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorobenzyl Standards
- 1-(2,3-Difluorobenzyl)-1h-1,2,4-triazol-3-amine (CAS 1182777-12-3)
- N-(3,5-difluorobenzyl)-4H-1,2,4-triazol-4-amine (CAS 1400635-46-2)
- 1-(2,5-Difluorobenzyl)-1h-1,2,3-triazol-4-amine (CAS 1511277-70-5)
- 1-(2,4-Difluorobenzyl)-1h-1,2,3-triazol-4-amine (CAS 1513438-62-4)
- 1-(2,5-Difluorobenzyl)-1H-pyrazol-4-ol (CAS 1597273-22-7)
- 1-(2,4-Difluorobenzyl)-1H-pyrazol-4-ol (CAS 1599994-09-8)
- 1-(3,5-Difluorobenzyl)-1H-pyrazol-4-ol (CAS 1600473-20-8)
- 1-(3,4-Difluorobenzyl)-1H-pyrazol-4-ol (CAS 1603188-42-6)
Recommended Standards
- 5-(difluoromethoxy)quinolin-8-amine (CAS 1594056-86-6)
- 4-[(ethoxycarbonyl)oxy]benzoic acid (CAS 15552-32-6)
- (5-(2,4-Difluorophenyl)oxazol-4-yl)methanamine (CAS 1521565-01-4)
- 4-Hydroxy-2-(methylthio)-6-(trifluoromethyl)pyrimidine (CAS 16097-62-4)
- (2Z)-2-[(Z)-4-Chlorobenzoyl]-3-(methylsulfanyl)-3-{[(pyridin-3-yl)methyl]amino}prop-2-enenitrile (CAS 866009-20-3)
- Beryllium sulfate (CAS 13510-49-1)
- 4-Methyl-N-(2-(piperazin-1-yl)ethyl)pentanamide hydrochloride (CAS 1827987-85-8)
- 4-Amino-5-(methylamino)pyrimidin-2-ol (CAS 527673-46-7)
- 6-(2H-Benzo[e][1,3]oxazin-3(4H)-yl)-N2-(3-(trimethoxysilyl)propyl)-1,3,5-triazine-2,4-diamine (CAS CATO-CIM-105737)
- Propargyl-PEG4-CH2CH2-Boc (CAS 1245823-50-0)
- 2-(1-Methyl-1H-pyrazol-4-yl)tetrahydrofuran-2-carboxylic acid (CAS 2137870-47-2)
- tert-Butyl 3-aminooctahydro-1H-indole-1-carboxylate (CAS 1782247-66-8)
- 1-Propyl-1H-indole-2,3-dione 3-hydrazone (CAS 726151-82-2)
- Calcium-Like Peptide 3 (CAS 261969-05-5)
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