4-Bromoquinoline-3-carboxylic acid methyl ester CAS 1601779-23-0
| CAS No. | 1601779-23-0 |
| Molecular Formula | C11H8BrNO2 |
| Molecular Weight | 266.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Bromoquinoline-3-carboxylic acid methyl ester (CAS 1601779-23-0) is a high-purity analytical reference standard with the molecular formula C11H8BrNO2 and a molecular weight of 266.09 g/mol.
The molecular framework of 4-Bromoquinoline-3-carboxylic acid methyl ester (C11H8BrNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Bromoquinoline-3-carboxylic acid methyl ester meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8BrNO2 |
| Molecular Weight | 266.09 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bromoquinoline Standards
- Methyl 7-Bromoquinoline-3-carboxylate (CAS 1001756-23-5)
- Methyl 2-Bromoquinoline-4-carboxylate (CAS 103502-48-3)
- Methyl 6-Bromoquinoline-3-carboxylate (CAS 1220418-77-8)
- Methyl 8-bromoquinoline-2-carboxylate (CAS 1242446-32-7)
- Methyl 6-bromoquinoline-8-carboxylate (CAS 1266728-34-0)
- Methyl 7-bromoquinoline-2-carboxylate (CAS 1267641-04-2)
- Methyl 4-bromoquinoline-8-carboxylate (CAS 132664-48-3)
- 6-Bromoquinoline-3-carbohydrazide (CAS 1333249-84-5)
Recommended Standards
- Methyl 6-bromoquinoline-4-carboxylate (CAS 1601063-72-2)
- 1-(4-Bromo-2-methylphenyl)-1H-pyrrole-2,5-dione (CAS 160207-20-5)
- 4-(4-Bromo-1H-pyrazol-1-yl)-3,3-difluoropiperidine (CAS 1534350-68-9)
- 1-Bromo-2-methyl-8-nitronaphthalene (CAS 167171-47-3)
- 1-[(3-Nitrophenyl)methyl]-2-(trifluoromethyl)-1H-1,3-benzodiazole (CAS 478030-52-3)
- Benzyl 3-(methylsulfamoyl)propanoate (CAS 1424042-10-3)
- 2-Methyl-5-(trifluoromethoxy)-3-(trifluoromethyl)pyridine (CAS 1803478-98-9)
- Racecadotril-D5 (CAS 1246815-11-1)
- 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indol-1-one (CAS 17952-82-8)
- ((2-Bromoallyl)oxy)(tert-butyl)dimethylsilane (CAS 293313-66-3)
- 2-(2-Fluoropyridin-3-yl)propan-2-ol hydrate (CAS 1186293-50-4)
- 2',4',6'-Trimethyl-5'-phenyl-1,1':3',1''-terphenyl (CAS 6231-26-1)
- 4-(Trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine (CAS 1256792-31-0)
- Semaglutide Impurity 137 (x TFA Salt) (CAS CATO-C4X-2226137)
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