Azacitidine Impurity 54 CAS 16033-23-1
| CAS No. | 16033-23-1 |
| Molecular Formula | C9H13N3O5 |
| Molecular Weight | 243.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Azacitidine Impurity 54 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Azacitidine Impurity 54 (CAS 16033-23-1, C9H13N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Azacitidine Impurity 54 (C9H13N3O5) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C9H13N3O5 |
| Molecular Weight | 243.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 3 |
Related Azacitidine Standards
- Azacitidine Impurity 28 (CAS 3530-56-1)
- Azacitidine Impurity 29 (CAS 26524-60-7)
- Azacitidine Impurity 43 (CAS 13913-16-1)
- Azacitidine Impurity 52 (CAS 77172-20-4)
- Azacitidine Impurity 53 (CAS 27921-78-4)
- Azacitidine Impurity 56 (CAS 154568-81-7)
- Azacitidine Impurity 57 (CAS 16110-07-9)
- Azacitidine Impurity 59 (CAS 89618-11-1)
Recommended Standards
- Azacitidine Impurity 60 (CAS 179239-81-7)
- Azacitidine Impurity 61 (CAS 18265-49-1)
- Milrinone Impurity 4 (CAS CATO-C4X-10914)
- Azacitidine Impurity 62 (CAS 201681-19-8)
- Tamsulosin EP Impurity F HCl (CAS 1051368-80-9)
- Simvastatin impurity 01 (CAS 1092716-42-1)
- Azacitidine Impurity 55 HCl (CAS 7428-39-9(free base))
- (E)-2-(2,4-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 736987-78-3)
- 1-(3-Fluorobenzyl)indoline-2,3-dione (CAS 689757-49-1)
- 2-Bromo-5-(chloromethyl)-3-(difluoromethyl)-4-methylpyridine (CAS 1806864-95-8)
- 5-(4-Ethoxyphenyl)-3-(thiophen-2-ylmethylene)furan-2(3H)-one (CAS 6781-91-5)
- 4-Chloro-2,6-difluoro-1,1'-biphenyl (CAS 180798-50-9)
- 4-(Bromomethyl)-2-(4-fluorophenyl)-5-methylthiazole (CAS 663909-23-7)
- D-[His]1-Semaglutide (CAS CATO-C4X-222652)
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