4-Chloro-2,6-difluoro-1,1'-biphenyl CAS 180798-50-9
| CAS No. | 180798-50-9 |
| Molecular Formula | C12H7ClF2 |
| Molecular Weight | 224.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-2,6-difluoro-1,1'-biphenyl (CAS 180798-50-9), molecular formula C12H7ClF2 and molecular weight 224.63 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C12H7ClF2, 4-Chloro-2,6-difluoro-1,1'-biphenyl contains fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 224.63 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF2 |
| Molecular Weight | 224.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4'-Chloro-2,3-difluoro-1,1'-biphenyl (CAS 477860-10-9)
- 5-Chloro-3,6-dimethylbenzofuran-2-carboxylic acid (CAS 1016-99-5)
- 4-Chloro-6-(3-fluorophenoxy)pyrimidine (CAS 1017067-02-5)
- 5-Chloro-3,7-dimethyl-1-benzofuran-2-carboxylic acid (CAS 1019115-66-2)
- N-(4-Chloro-2-methoxyphenyl)-2-cyanoacetamide (CAS 1072069-59-0)
- Ethyl 5-chloro-1H-indazole-3-carboxylate (CAS 1081-05-6)
- 2-chloro-4-(4-fluorophenoxy)pyrimidine (CAS 1090835-72-5)
- 5-(3-chloro-4-fluorophenyl)-1,2,4-triazin-3-amine (CAS 1094231-67-0)
Recommended Standards
- 4,4,4-trifluoro-2-methylbutane-1-sulfonyl chloride (CAS 1784373-64-3)
- 1-(2-Chloroethyl)tetrahydro-1H,5H-[1,3,2]diazaphospholo[2,1-β][1,3,2]oxazaphosphorine 9-Oxide (CAS 64724-10-3)
- 3,3,3-Trifluoro-2,2-dimethylpropane-1-sulfonyl chloride (CAS 1783625-32-0)
- 2-(aziridin-1-yl)-3-(2-chloroethyl)-1,3,2-oxazaphosphinane 2-oxide (CAS 29102-47-4)
- N-[(4-Methoxyphenyl)methyl]-2-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775308-43-4)
- Ethyl 3-amino-3-(thiophen-2-yl)acrylate (CAS 212761-76-7)
- N-Boc-N-(4-piperidylmethyl)ethanamine (CAS 158958-41-9)
- (R,E)-3,7-Dihydroxy-2-(prop-1-en-1-yl)-6,7-dihydropyrano[2,3-c]pyrrole-4,5-dione (CAS 773855-65-5)
- 2-Chloro-5-(pyrrolidine-1-sulfonyl)pyridine (CAS 64614-51-3)
- N',4-Dimethyl-1H-pyrazole-3-carbohydrazide (CAS 89270-60-0)
- 6-Allyl-8β-carboxyergoline Methyl Ester (CAS 72821-79-5)
- Hexachloro-1,3-butadiene-13C4 (CAS 93951-70-3)
- 3,4-Dibromo-1-methyl-pyrazole (CAS 89607-14-7)
- [Ser39-OH] Tirzepatide (CAS CATO-C4X-324041)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com