Zidovudine Impurity F CAS 16053-52-4
| CAS No. | 16053-52-4 |
| Molecular Formula | C10H14N2O5 |
| Molecular Weight | 242.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 242.23 g/mol gives Zidovudine Impurity F distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Zidovudine Impurity F (CAS 16053-52-4) is a certified pharmaceutical impurity reference standard with the molecular formula C10H14N2O5 and a molecular weight of 242.23 g/mol.
Zidovudine Impurity F (C10H14N2O5) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Zidovudine Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H14N2O5 |
| Molecular Weight | 242.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 2 |
Related Zidovudine Standards
- Zidovudine Impurity 19 (CAS CATO-C4X-178319)
- Zidovudine EP Impurity D (CAS 76-84-6)
- Zidovudine EP Impurity B (CAS 25526-94-7)
- Zidovudine Impurity 04 (CAS 73971-82-1)
- Zidovudine Impurity 13 (CAS 123606-70-2)
- Zidovudine-d4 (CAS CATO-C4X-178320)
- Zidovudine EP Impurity K (CAS 596-31-6)
- Zidovudine impurity B (CAS 61008-98-8)
Recommended Standards
- Ethyl 5-(4-Cyanophenyl)isoxazole-3-carboxylate (CAS 160411-70-1)
- 2-Nitro-10,11-dihydrodibenzo[b,f][1,4]oxazepine (CAS 16398-30-4)
- 2,5-Bis(prop-2-yn-1-yloxy)terephthalaldehyde (CAS 1538579-23-5)
- 5-Hydroxy-2-methyl-naphtho[1,2-b]furan-3-carboxylic acid (CAS 17112-91-3)
- Cilastatin E-isomer Impurity 18 (CAS CATO-C4X-196018)
- Ritonavir Impurity 58 (CAS 172720-22-8)
- Ilaprazole impurity 184 (CAS CATO-C4X-1130184)
- Vonoprazan Impurity 245 (CAS CATO-C4X-1020245)
- 3-bromo-1,2-thiazole-4-carboxylic acid (CAS 1309469-83-7)
- Methyl 2-((4-nitrobenzyl)thio)acetate (CAS 6625-36-1)
- 3-(5-Fluoro-2-methylphenyl)propan-1-ol (CAS 1000551-43-8)
- 7-Methoxy-3-(thiophen-2-yl)isobenzofuran-1(3H)-one (CAS 91362-88-8)
- 7-Nitro-10-octyl-3-phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (CAS 137346-42-0)
- Semaglutide impurity 193 (CAS CATO-C4X-2226193)
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