2-Amino-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)phenol CAS 161949-58-2

Purity 97%+In StockPharmaceutical Standards
CAS No.161949-58-2
Molecular FormulaC12H8ClF3N2O
Molecular Weight288.65 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-Amino-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)phenol CAS 161949-58-2 chemical structure

Description

2-Amino-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)phenol (CAS 161949-58-2), molecular formula C12H8ClF3N2O and molecular weight 288.65 g/mol, is a CATO reference standard with documented purity and traceability.

2-Amino-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)phenol (C12H8ClF3N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-Amino-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)phenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC12H8ClF3N2O
Molecular Weight288.65 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2003
Halogen ContentF/Cl-containing
Nitrogen Atoms2

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