4-Chloro-7-fluoro-6-nitroquinazoline CAS 162012-70-6
| CAS No. | 162012-70-6 |
| Molecular Formula | C8H3ClFN3O2 |
| Molecular Weight | 227.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-7-fluoro-6-nitroquinazoline.
CATO supplies 4-Chloro-7-fluoro-6-nitroquinazoline (CAS 162012-70-6), a certified reference material (molecular formula C8H3ClFN3O2, MW 227.58 g/mol) for analytical method development and quality control.
The molecular framework of 4-Chloro-7-fluoro-6-nitroquinazoline (C8H3ClFN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-Chloro-7-fluoro-6-nitroquinazoline under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H3ClFN3O2 |
| Molecular Weight | 227.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- Ethyl 3-chloro-2-cyano-4,4,4-trifluorobut-2-enoate (CAS 77429-04-0)
- 2-Chloro-6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-ol (CAS 344776-74-5)
- 1-Bromo-8-chlorooctane (CAS 28598-82-5)
- 3-Chloro-2-methoxy-5-(trifluoromethyl)pyridine 1-oxide (CAS 1823188-17-5)
- Tapi-2 (CAS 187034-31-7)
- N-Ethyl-1H-pyrrolo[2,3-b]pyridin-6-amine (CAS 918510-54-0)
- Ethyl 4-(4-bromobenzoyl)isoxazole-3-carboxylate (CAS 338408-83-6)
- Arotinolol Impurity 67 (CAS CATO-C4X-185467)
- 1-Acetyl-4-cyanopiperidine (CAS 25503-91-7)
- 4-Chloro-5,6-difluoronicotinic acid (CAS 851386-32-8)
- 6-Bromo-2-(trifluoromethyl)-1H-indol-4-amine (CAS 2414146-34-0)
- Indometacin EP Impurity H (CAS 1601-18-9)
- 1-(propylsulfonyl)piperidin-4-amine (CAS 748768-34-5)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com