Indometacin EP Impurity H CAS 1601-18-9
| CAS No. | 1601-18-9 |
| Molecular Formula | C20H18ClNO4 |
| Molecular Weight | 371.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Indometacin EP Impurity H (CAS 1601-18-9) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18ClNO4 and a molecular weight of 371.81 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Indometacin EP Impurity H is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 371.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Indometacin EP Impurity H under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H18ClNO4 |
| Molecular Weight | 371.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Indometacin Standards
- Indometacin EP Impurity D (CAS CATO-C4X-147012)
- Indometacin EP Impurity E (CAS 807614-94-4)
- Indometacin Impurity 47 (CAS CATO-C4X-147047)
- Indometacin Impurity 54 (CAS CATO-C4X-147054)
- Indometacin Impurity 65 (CAS CATO-C4X-147065)
- Indometacin EP Impurity I (CAS 16401-99-3)
- Indometacin Impurity 55 (CAS CATO-C4X-147055)
- Indometacin EP Impurity G (CAS 402849-26-7)
Recommended Standards
- Ethyl N-(2-chlorophenyl)-N-((4-fluorophenyl)sulfonyl)glycinate (CAS 860609-48-9)
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- Cefotaxime EP Impurity B (CAS 66340-28-1)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com