2-[3-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]acetamide CAS 1627857-32-2
| CAS No. | 1627857-32-2 |
| Molecular Formula | C14H19BFNO3 |
| Molecular Weight | 279.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-[3-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]acetamide.
2-[3-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]acetamide (CAS 1627857-32-2) is a high-purity analytical reference standard with the molecular formula C14H19BFNO3 and a molecular weight of 279.11 g/mol.
2-[3-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]acetamide (C14H19BFNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H19BFNO3 |
| Molecular Weight | 279.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- N-(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (CAS 1150271-55-8)
- N-(5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (CAS 1150271-67-2)
- 7-Fluoro-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester, 97% (CAS 1256255-84-1)
- 8-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine (CAS 1256255-96-5)
- 5-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 1256256-02-6)
- N-[2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide (CAS 1356943-52-6)
- N-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (CAS 1638329-59-5)
- 2-Fluoro-n-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (CAS 2377607-34-4)
Recommended Standards
- 4-bromo-3-methanesulfonylbenzoic acid (CAS 158608-01-6)
- 3-Bromo-5-sulfamoylbenzamide (CAS 1478215-51-8)
- 4-(Fluoromethyl)-5-(trifluoromethoxy)-2-(trifluoromethyl)pyridin-3-ol (CAS 1804794-48-6)
- 5-Bromo-2-(methylsulfonyl)benzoic acid (CAS 146431-33-6)
- Orientin 2-O-p-trans-coumarate (CAS 1229437-75-5)
- 1,2,3,4-Tetrahydroisoquinoline-8-carbonitrile (CAS 215798-85-9)
- 1-(4-(o-Tolyl)thiazol-2-yl)guanidine (CAS 123309-87-5)
- 1-(2,3-dihydro-1H-isoindol-5-yl)propan-1-one hydrochloride (CAS 1803595-01-8)
- 6-Fluoro-2-methylbenzothiazole (CAS 399-73-5)
- 3-Formyl-5-hydroxy-N,N-dimethylbenzamide (CAS 1243440-09-6)
- 4'-((7-Hydroxy-5-propylpyrazolo[1,5-a]pyrimidin-6-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid (CAS 167375-28-2)
- 2-(3,5-Dimethyl-1H-pyrazole-1-carbonyl)-4-(3-fluorophenyl)-N-methyl-N-(4-methylphenyl)thiophene-3-sulfonamide (CAS 1173770-07-4)
- 1-Ethoxy-5-phenylpentan-2-ol (CAS 1491406-84-8)
- Semaglutide impurity 99 (CAS CATO-C4X-222699)
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