Esomeprazole impurity 127 CAS 16282-23-8
| CAS No. | 16282-23-8 |
| Molecular Formula | C7H9NO2 |
| Molecular Weight | 139.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Esomeprazole impurity 127 is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Esomeprazole impurity 127 (CAS 16282-23-8, C7H9NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Esomeprazole impurity 127 is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 139.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H9NO2 |
| Molecular Weight | 139.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 1 |
Related Esomeprazole Standards
- Esomeprazole Impurity 45 (CAS 37466-89-0)
- Esomeprazole Impurity 108 (CAS 74409-42-0)
- Esomeprazole Impurity 112 (CAS 202932-05-6)
- Esomeprazole Impurity N1 (CAS 848696-99-1)
- Esomeprazole Impurity 116 (CAS 109371-19-9)
- Esomeprazole Impurity 94 (CAS 91219-89-5)
- Esomeprazole Impurity 33 (CAS 615-72-5)
- Esomeprazole Impurity 92 (CAS 3718-65-8)
Recommended Standards
- Rupatadine Impurity 23 (CAS 21636-51-1)
- Lansoprazole Impurity 35 (CAS 1797131-12-4)
- 3,5-Dimethoxypyridine (CAS 18677-48-0)
- Ilaprazole Impurity 161 (CAS CATO-C4X-1130161)
- Levofloxacin Impurity 98 (CAS CATO-C4X-137198)
- Ponatinib Impurity 33 (CAS CATO-C4X-226933)
- Fluvoxamine EP Impurity C (CAS 259526-43-7)
- (3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)methanol (CAS 1314143-65-1)
- L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-2-propyn-1-yl-, 2,5-dioxo-1-pyrrolidinyl ester (CAS 1800210-74-5)
- Cyclohexyl sulfamate (CAS 20655-61-2)
- (11aR)-10,11,12,13-Tetrahydro-5-hydroxy-3,7-diphenyl-diindeno[7,1-de:1,7-fg][1,3,2]dioxaphosphocin (CAS 1297613-72-9)
- 4-(2-Bromoethyl)benzenesulfonyl chloride (CAS 64062-91-5)
- (R)-2,2,2-Trifluoro-1-p-tolyl-ethylamine hydrochloride (CAS 1391458-37-9)
- MOTS-c Peptide (CAS 1627580-64-6)
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