2-(3-Chloro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1628502-45-3
| CAS No. | 1628502-45-3 |
| Molecular Formula | C13H18BClO3 |
| Molecular Weight | 268.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-(3-Chloro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-(3-Chloro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1628502-45-3), molecular formula C13H18BClO3 and molecular weight 268.54 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(3-Chloro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (C13H18BClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C13H18BClO3 |
| Molecular Weight | 268.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 3-Chloro-4-(hydroxymethyl)phenylboronic Acid Pinacol Ester (CAS 1051316-34-7)
- 2-(2-Chloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1061367-22-3)
- 3-Chloro-5-(hydroxymethyl)phenylboronic Acid Pinacol Ester (CAS 1112210-59-9)
- 2-Chloro-3-methoxyphenylboronic Acid Pinacol Ester (CAS 1151564-03-2)
- 2-(3-Chloro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1165936-01-5)
- 2-(2-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1256781-73-3)
- 2-Chloro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1294518-25-4)
- 2-Chloro-3-(hydroxymethyl)phenylboronic Acid Pinacol Ester (CAS 1400755-07-8)
Recommended Standards
- 3-Bromo-4-phenyl-2-chloropyridine (CAS 1622838-93-0)
- 3-Chloro-4-hydroxy-2-methylphenylboronic Acid Pinacol Ester (CAS 1799612-10-4)
- (4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (CAS 1544673-40-6)
- 4-Chloro-3-(hydroxymethyl)phenylboronic Acid Pinacol Ester (CAS 1799974-98-3)
- 2-(2-Oxo-5-phenyl-2,3-dihydro-1,3,4-oxadiazol-3-yl)acetic acid (CAS 71679-70-4)
- Acetophenazine (CAS 2751-68-0)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(pyridin-4-yl)acetic acid (CAS 1228542-27-5)
- [3-chloro-5-(ethanesulfonyl)phenyl]methanamine (CAS 1565935-59-2)
- Dicyclohexyliodoborane (CAS 55382-85-9)
- 1-(3-Bromo-4-(dimethylamino)phenyl)ethan-1-one (CAS 142500-11-6)
- Methyl 5-(thiophen-2-yl)oxazole-4-carboxylate (CAS 85210-60-2)
- 4-(Benzo[b]thiophene-3-sulfonyl)-piperazine hydrochloride (CAS 864759-61-5)
- 4-Cyclopropyl-8-ethoxyisoquinoline-6-carboxylic acid (CAS 921761-15-1)
- D-[Ser]8-Semaglutide (CAS CATO-CPTD788632)
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