2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine CAS 1628524-90-2
| CAS No. | 1628524-90-2 |
| Molecular Formula | C12H14BF4NO2 |
| Molecular Weight | 291.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine (CAS 1628524-90-2), molecular formula C12H14BF4NO2 and molecular weight 291.05 g/mol, is a CATO reference standard with documented purity and traceability.
2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine (C12H14BF4NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14BF4NO2 |
| Molecular Weight | 291.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 2-Fluoro-5-(trifluoromethyl)pyridine-3-boronic acid pinacol ester, 97% (CAS 1128269-66-8)
- 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine (CAS 1169459-44-2)
- 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine (CAS 1984826-57-4)
- (3-Fluoro-4-((2-fluorobenzyl)carbamoyl)phenyl)boronic acid (CAS 1449132-63-1)
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- 2-Fluoro-5-(2-fluorobenzylcarbamoyl)benzeneboronic acid (CAS 1449144-70-0)
Recommended Standards
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- 3-(5-Bromo-2-(difluoromethoxy)phenyl)propiolic acid (CAS 1403565-96-7)
- 2-(2-Bromo-4-cyano-6-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805357-02-1)
- 3-Cyano-5-methyl-N-(pyridin-2-yl)-1,2-oxazole-4-carboxamide (CAS 400076-15-5)
- 3-{5,7-dioxo-5h,6h,7h-pyrrolo[3,4-b]pyrazin-6-yl}propanoic acid (CAS 126310-28-9)
- 1-(1,1-Dimethyl-2-propyn-1-yl)-piperidine (CAS 6340-49-4)
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- (S)-5-(Difluoromethyl)-2,3-dihydro-1H-inden-1-amine (CAS 1213891-24-7)
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- 1-(2-Ethyl-1h-imidazol-1-yl)propan-2-amine (CAS 1248743-57-8)
- 4-(tert-Butyl)-5-(trifluoromethyl)thiophene-2-carbaldehyde (CAS 1260665-45-9)
- 4-((2,3-Dichlorophenyl)thio)-5-methoxy-2-phenylpyrimidine (CAS 477872-61-0)
- Insulin Pork(≥27 USP units/mg) (CAS 12584-58-6)
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