2-(2-Bromo-4-cyano-6-(difluoromethyl)pyridin-3-yl)acetic acid CAS 1805357-02-1
| CAS No. | 1805357-02-1 |
| Molecular Formula | C9H5BrF2N2O2 |
| Molecular Weight | 291.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2-Bromo-4-cyano-6-(difluoromethyl)pyridin-3-yl)acetic acid.
CATO supplies 2-(2-Bromo-4-cyano-6-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805357-02-1), a certified reference material (molecular formula C9H5BrF2N2O2, MW 291.05 g/mol) for analytical method development and quality control.
The molecular framework of 2-(2-Bromo-4-cyano-6-(difluoromethyl)pyridin-3-yl)acetic acid (C9H5BrF2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H5BrF2N2O2 |
| Molecular Weight | 291.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 3-(5-Bromo-2-(difluoromethoxy)phenyl)propiolic acid (CAS 1403565-96-7)
- 2-(2-Bromo-5,6-difluorobenzofuran-3-yl)acetic acid (CAS 1420792-84-2)
- 2-(2-Bromo-4-cyano-5-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1804493-35-3)
- 2-(2-Bromo-6-cyano-4-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805357-07-6)
- 2-(6-Bromo-5-cyano-2-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805371-63-4)
- 2-(2-Bromo-5-cyano-3-(difluoromethyl)pyridin-4-yl)acetic acid (CAS 1805388-30-0)
- 2-(6-Bromo-2-cyano-5-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805388-36-6)
- 2-(2-Bromo-3-cyano-5-(difluoromethyl)pyridin-4-yl)acetic acid (CAS 1805432-28-3)
Recommended Standards
- 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine (CAS 1628524-90-2)
- 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine (CAS 1169459-44-2)
- 2-Fluoro-5-(trifluoromethyl)pyridine-3-boronic acid pinacol ester, 97% (CAS 1128269-66-8)
- 2-(2-Bromo-5-cyano-4-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805432-35-2)
- 2,6-Bis[(4S)-4,5-dihydro-4-[2-(methylthio)ethyl]-2-oxazolyl]pyridine (CAS 497172-32-4)
- 1,4-Cyclohexadiene-1,2-dicarboxylicanhydride (CAS 4773-89-1)
- 2-Bromo-4-(bromomethyl)-6-(difluoromethyl)-3-methylpyridine (CAS 1805930-20-4)
- 4-Hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid (CAS 56406-45-2)
- (2r)-5-Hexyl-4-hydroxy-2-undecyl-2,3-dihydropyran-6-one (CAS 112764-00-8)
- 5-(2,6-Dichloropyridin-4-yl)-1,3,4-oxadiazole-2-thiol (CAS 119221-62-4)
- diethyl 2-[(4-fluoroanilino)methylene]malonate (CAS 26832-96-2)
- 8-Methoxy-2-oxo-2H-chromene-3-carboxylic Acid (CAS 2555-20-6)
- Cinacalcet Impurity 19 (CAS 22038-83-1)
- Semaglutide impurity 76 (CAS CATO-C4X-222676)
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