R,R,S-Ezetimibed CAS 163380-16-3
| CAS No. | 163380-16-3 |
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of R,R,S-Ezetimibed is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies R,R,S-Ezetimibed (CAS 163380-16-3), a certified reference material (molecular formula C24H21F2NO3, MW 409.43 g/mol) for analytical method development and quality control.
Structurally, R,R,S-Ezetimibed (C24H21F2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 409.43 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Ezetimibe (CAS 163222-33-1)
- Ezetimibe meta-Fluorobenzene Isomer (CAS CATO-C4X-1098127)
- trans-1-(4-Fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one (CAS 947332-80-1)
- Ezetimibe Lactone Impurity 128 (CAS CATO-C4X-1098128)
- 3-bromo-4-ethoxybenzene-1-sulfonamide (CAS 749253-28-9)
- 2-(1H-Imidazol-5-yl)acetic acid (CAS 645-65-8)
- 2-(((1-((Benzyloxy)carbonyl)piperidin-4-yl)methyl)(ethyl)amino)acetic acid (CAS 1353962-26-1)
- Rel-(1s,3s)-1-bromo-3-(tert-butoxy)cyclobutane (CAS 1955474-99-3)
- 2-(Piperidin-4-yl)azepane-1-carboxamide (CAS 1334148-10-5)
- 5-Amino-3-bromo-2-methoxypyridine (CAS 53242-18-5)
- N1-(Isoquinolin-1-yl)-N1-phenyloxalamide (CAS 62472-04-2)
- 4-Chloro-1-(p-tolyl)butan-1-one (CAS 38425-26-2)
- 3-Chloro-6-hydroxy-2-(trifluoromethyl)pyridine (CAS 1227514-31-9)
- Delicious Peptide (bovine) (CAS 73984-05-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com