trans-1-(4-Fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one CAS 947332-80-1
| CAS No. | 947332-80-1 |
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
trans-1-(4-Fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one (CAS 947332-80-1), molecular formula C24H21F2NO3 and molecular weight 409.43 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of trans-1-(4-Fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one (C24H21F2NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related trans Standards
- 1-(4-Fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one (CAS 439081-02-4)
- 1-[Bis(4-fluorophenyl)methyl]-4-(4-nitrophenyl)piperazine (CAS 851472-82-7)
- (S)-5-(1-(1-(4-Fluorophenyl)ethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)benzo[d]oxazole (CAS 2123491-32-5)
- N-(2-Fluorophenyl)-2-((7-methyl-4-oxo-8-phenyl-3,4-dihydropyrazolo[1,5-a][1,3,5]triazin-2-yl)thio)acetamide (CAS 946247-48-9)
- 1-(4-{[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidin-1-yl)-2-(4-methylphenoxy)ethan-1-one (CAS 1775455-69-0)
- N-(4-fluorophenyl)-1,3-dimethyl-5-((3-(trifluoromethyl)phenyl)thio)-1H-pyrazole-4-carboxamide (CAS 303997-97-9)
- 1-[2-[bis(4-Fluorophenyl)methoxy]ethyl]-4-(pyridinyl)-piperazine (CAS 154558-38-0)
- 3-Ethyl-5-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one (CAS 302938-07-4)
Recommended Standards
- FMoc-dl-glu(oall)-oh (CAS 366491-50-1)
- Ezetimibe (CAS 163222-33-1)
- Fmoc-d-glu-oall (CAS 204251-86-5)
- R,R,S-Ezetimibed (CAS 163380-16-3)
- 3-Cyclopropyl-5-oxa-2-azaspiro[3.4]Octan-1-one (CAS 1820687-31-7)
- 4-Hydroxydecanoic acid (CAS 17369-51-6)
- (3-(Difluoro(phenyl)methyl)bicyclo[1.1.1]Pentan-1-yl)methanol (CAS 2169049-75-4)
- 4-Chloro-3-fluorobenzenesulfonamide (CAS 942035-78-1)
- 5-Bromo-4-isopropoxy-2-methylaniline (CAS 1374652-11-5)
- Flibanserin Impurity 13 (CAS 55470-74-1)
- 2-Cyclopropoxy-4-isopropoxy-1-isopropylbenzene (CAS 1243470-26-9)
- 2-Allyl-3-bromothiophene (CAS 33892-67-0)
- 3-[3-(benzyloxy)phenyl]propanenitrile (CAS 1027082-48-9)
- Peptide Impurity 09 X TFA Salt (CAS CATO-CPTD788809)
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