Methenamine Impurity 4 CAS 16352-36-6
| CAS No. | 16352-36-6 |
| Molecular Formula | C10H21N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methenamine Impurity 4 is closely related to a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Methenamine Impurity 4 (CAS 16352-36-6), a pharmacopoeial impurity reference standard (molecular formula C10H21N5Cl, MW 246.76 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrile group, chlorine substitution, Methenamine Impurity 4 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 246.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Methenamine Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H21N5 Cl |
| Molecular Weight | 246.76 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.5 |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Methenamine Standards
Recommended Standards
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- Edoxaban Impurity 86 (CAS CATO-C4X-106386)
- 2-Chloro-5-ethynyl-3-iodopyridin-4-amine (CAS 1353877-92-5)
- 2,5-Dimethyl-1-phenyl-1H-imidazole-4-carboxylic acid (CAS 906804-17-9)
- N-Acetyl-S-(2-hydroxy-3-butenyl)cysteine (CAS 159092-64-5)
- Semaglutide impurity 60 (CAS CATO-C4X-222660)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com