4-(4-Fluorophenyl)piperidine-2,6-dione CAS 163631-01-4
| CAS No. | 163631-01-4 |
| Molecular Formula | C11H10FNO2 |
| Molecular Weight | 207.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(4-Fluorophenyl)piperidine-2,6-dione (C11H10FNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
4-(4-Fluorophenyl)piperidine-2,6-dione (CAS 163631-01-4) is a high-purity analytical reference standard with the molecular formula C11H10FNO2 and a molecular weight of 207.20 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10FNO2 |
| Molecular Weight | 207.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorophenyl Standards
- 2-(5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl)ethanamine (CAS 1017346-04-1)
- (3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)methanol (CAS 1018297-63-6)
- [2-(4-Fluorophenyl)-4-methyl-1,3-oxazol-5-yl]methanol (CAS 109544-11-8)
- (2-(4-Fluorophenyl)-5-methyloxazol-4-yl)methanol (CAS 109544-18-5)
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- (3-(3-Fluorophenyl)-5-methylisoxazol-4-yl)methanol (CAS 1159251-38-3)
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Recommended Standards
- Ethyl 3-fluoro-1H-indole-2-carboxylate (CAS 1552269-44-9)
- Methyl 4-(1,1-difluoroethyl)thiazole-2-carboxylate (CAS 1644548-97-9)
- 6-(4-Fluorophenyl)piperidine-2,4-dione (CAS 1545134-39-1)
- 3-Ethyl-5-fluoro-1H-indole-2-carboxylic acid (CAS 169674-67-3)
- (3r)-1-(3-Aminopropyl)pyrrolidin-3-ol (CAS 956948-81-5)
- 7-Naphthalenedisulfonic Acid (CAS 5724-16-3)
- (1S,2R,4R)-7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid (CAS 1048963-21-8)
- (4-(Azepan-1-ylmethyl)phenyl)methanamine (CAS 876716-67-5)
- 8-Bromo-4-chloro-6-(trifluoromethyl)quinoline (CAS 1065093-23-3)
- 2-(Furan-3-yl)-1H-benzo[d]imidazol-1-ol (CAS 691353-45-4)
- (E)-N-((1-(3-Cyanopyrazin-2-yl)piperidin-4-yl)methyl)-3-(furan-3-yl)acrylamide (CAS 1798428-54-2)
- 2-Chlorothiazolo[4,5-b]pyridine (CAS 152170-30-4)
- 2,2,2-Trifluoro-1-(4-pentylphenyl)ethan-1-amine (CAS 886369-34-2)
- D-allo-Thr7-Semaglutide (CAS CATO-C4X-2226242)
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