Bromo-Afatinib CAS 1637254-93-3
| CAS No. | 1637254-93-3 |
| Molecular Formula | C22H35BrClFN4O3 |
| Molecular Weight | 537.89 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bromo-Afatinib.
Bromo-Afatinib (CAS 1637254-93-3) is a high-purity analytical reference standard with the molecular formula C22H35BrClFN4O3 and a molecular weight of 537.89 g/mol.
Bromo-Afatinib (C22H35BrClFN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H35BrClFN4O3 |
| Molecular Weight | 537.89 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
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- N,N-Diethyl-3-[5-mercapto-4-(3-trifluoromethyl-phenyl)-4H-[1,2,4]triazol-3-yl]-benzenesulfonamide (CAS 721415-63-0)
- 3-Methyl-5,5-diphenyl-2-thioxoimidazolidin-4-one (CAS 21083-48-7)
- (2S)-2-amino-N-(1-(3-chlorophenyl)ethyl)-3-methylbutanamide (CAS 1309049-94-2)
- Cycloaspeptide A (CAS 109171-13-3)
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