Tetrabenazine Impurity 44 CAS 1637279-07-2
| CAS No. | 1637279-07-2 |
| Molecular Formula | C8H10BrNO2 |
| Molecular Weight | 232.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Tetrabenazine Impurity 44 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 232.07 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Tetrabenazine Impurity 44 (CAS 1637279-07-2, C8H10BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tetrabenazine Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H10BrNO2 |
| Molecular Weight | 232.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Tetrabenazine Standards
- Tetrabenazine Impurity 39 (CAS CATO-C4X-274839)
- Tetrabenazine Impurity 3 (CAS 14301-36-1)
- Tetrabenazine Impurity 40 (CAS 135675-32-0)
- Tetrabenazine Impurity 6 (CAS 1159511-98-4)
- Tetrabenazine Impurity 16 (CAS 191847-31-1)
- Tetrabenazine Impurity 63 (CAS 39816-38-1 (non-labelled))
- Tetrabenazine Impurity 64 (CAS 282721-32-8 (non-labelled))
- Tetrabenazine Impurity 69 (CAS CATO-C4X-274869)
Recommended Standards
- Phloroglucinol impurity 44 (CAS 23957-21-3)
- 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol (CAS 355-80-6)
- 87-48-9 5-Bromoisatin 5-Bromoindoline-2,3-dione 1H-Indole-2,3-dione, 5-bromo- (9CI) Indole-2,3-dione, 5-bromo- 5-21-10-00264 (Beilstein Handbook Reference) BRN 0383760 5-Bromisatin [Czech] 5-Bromoindole-2,3-dione EINECS 201-747-7 Isatin, 5-bromo- NSC 4980 5-Bromisatin (CAS 87-48-9)
- 1005668-21-2 2-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)acetamide 7201AC C7H10BrN3O (CAS 1005668-21-2)
- Diosmin EP Impurity F (CAS 520-34-3)
- Aztreonam impurity 62 (CAS CATO-C4X-152262)
- Fudosteine impurity 50 (CAS CATO-C4X-144750)
- 4-(3-(Oxazol-5-yl)phenyl)morpholine (CAS 2197063-23-1)
- 2-(2-Oxo-1,2-dihydropyridin-3-yl)piperidine-1-carbaldehyde (CAS 1352494-23-5)
- 3,4-Dimethyl-5-nitro-N-((tetrahydrofuran-2-yl)methyl)benzenesulfonamide (CAS 898647-58-0)
- Methyl 4-((tert-butoxycarbonyl)amino)pyrrolidine-2-carboxylate (CAS 1539388-39-0)
- Imatinib Impurity 49 (CAS CATO-C4X-106849)
- Clonazepam impurity 18 (CAS 23751-99-7)
- Neuropeptide K, porcine (CAS 106441-70-7)
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