Ibrutinib Impurity 48 CAS 1642571-08-1
| CAS No. | 1642571-08-1 |
| Molecular Formula | C27H30N6O3 |
| Molecular Weight | 486.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Ibrutinib Impurity 48 (CAS 1642571-08-1) is a certified pharmaceutical impurity reference standard with the molecular formula C27H30N6O3 and a molecular weight of 486.57 g/mol.
Based on its molecular formula C27H30N6O3, Ibrutinib Impurity 48 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 486.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C27H30N6O3 |
| Molecular Weight | 486.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 177 (CAS CATO-C4X-1064177)
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- Ibrutinib Impurity 191 (CAS CATO-C4X-1064191)
- Ibrutinib Impurity 164 (CAS CATO-C4X-1064164)
- Ibrutinib Impurity 165 (CAS CATO-C4X-1064165)
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- Ibrutinib Impurity 38 (CAS CATO-C4X-106438)
- Ibrutinib Impurity 108 (CAS CATO-C4X-1064108)
Recommended Standards
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- 1-(4-Methoxyphenyl)-2-(quinolin-2-yl)ethan-1-ol (CAS 94004-77-0)
- 2,2,6,6-Tetramethyl-1-nitrosopiperidin-4-one (CAS 640-01-7)
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- 3-(2-Fluorophenyl)-1-methyl-1H-pyrazol-5-ol (CAS 179117-86-3)
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