Ibrutinib Impurity 47 CAS 1022150-11-3
| CAS No. | 1022150-11-3 |
| Molecular Formula | C27H30N6O3 |
| Molecular Weight | 486.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ibrutinib Impurity 47.
Ibrutinib Impurity 47 (CAS 1022150-11-3) is a certified pharmaceutical impurity reference standard with the molecular formula C27H30N6O3 and a molecular weight of 486.57 g/mol.
Ibrutinib Impurity 47 (C27H30N6O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ibrutinib Impurity 47 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H30N6O3 |
| Molecular Weight | 486.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 177 (CAS CATO-C4X-1064177)
- Ibrutinib Impurity 48 (CAS 1642571-08-1)
- Ibrutinib Impurity 191 (CAS CATO-C4X-1064191)
- Ibrutinib Impurity 164 (CAS CATO-C4X-1064164)
- Ibrutinib Impurity 165 (CAS CATO-C4X-1064165)
- Ibrutinib Impurity 36 (CAS CATO-C4X-106436)
- Ibrutinib Impurity 38 (CAS CATO-C4X-106438)
- Ibrutinib Impurity 108 (CAS CATO-C4X-1064108)
Recommended Standards
- tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (CAS 936563-86-9)
- Linagliptin Impurity 65 (CAS CATO-C4X-110165)
- 2-Imino-1-(3-morpholinopropyl)-5-oxo-N-(1-phenylethyl)-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide (CAS 510761-83-8)
- Methyl 2-((5,6-dimethyl-2H-pyran-2-yl)(ethoxy)amino)-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate (CAS 335407-06-2)
- Daprodustat Impurity 45 (CAS CATO-C4X-240745)
- Others Impurity 20 (CAS CATO-C3D-262620)
- Travoprost Impurity 14 (CAS 54094-19-8)
- 2-Iodo-4-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1227270-47-4)
- 1-Cyclopropyl-1H-pyrazol-4-ol (CAS 1881329-88-9)
- (6-(Isopropylamino)pyridin-3-yl)(phenyl)methanone (CAS 1355204-55-5)
- 2-(((6-Bromo-1H-indol-3-yl)methyl)thio)ethanamine (CAS 99102-23-5)
- 4-(cyclopropylmethoxy)-3-hydroxybenzoic acid (CAS 1243391-01-6)
- Ceftizoxime Impurity 47 (CAS CATO-C4X-179347)
- Human glucagon CRS (CAS 9007-92-5)
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