Dabigatran Impurity 27 CAS 1642853-67-5
| CAS No. | 1642853-67-5 |
| Molecular Formula | C19H20N4O4 |
| Molecular Weight | 368.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 368.39 g/mol gives Dabigatran Impurity 27 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Dabigatran Impurity 27 (CAS 1642853-67-5, C19H20N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H20N4O4, Dabigatran Impurity 27 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 368.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H20N4O4 |
| Molecular Weight | 368.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 4 |
Related Dabigatran Standards
- Dabigatran Impurity 28 (CAS 1456889-80-7)
- Dabigatran Impurity 116 (CAS CATO-C4X-1089116)
- Dabigatran Impurity 67 (CAS 429659-01-8)
- Dabigatran Impurity 100 (CAS CATO-C4X-1089100)
- Dabigatran Impurity 107 (CAS CATO-C4X-1089107)
- Dabigatran Impurity 113 (CAS CATO-C4X-1089113)
- Dabigatran Impurity 127 (CAS 1422435-37-7)
- Dabigatran Impurity 15 (CAS 1702936-92-2)
Recommended Standards
- tert-Butyl 4-(cyanomethyl)-4-(4-(trifluoromethyl)phenyl)piperidine-1-carboxylate (CAS 878130-39-3)
- Alogliptin Impurity 98 (CAS CATO-C4X-109998)
- N-((1,3-Diphenyl-1H-pyrazol-5-yl)methylene)-4-nitroaniline (CAS 89185-70-6)
- Finerenone Impurity 59 (CAS CATO-C4X-288059)
- Betacarotene EP Impurity C (CAS CATO-C4X-28153)
- Lamivudine Sulfone (CAS 2250242-24-9)
- Tigecycline Impurity 26 (CAS CATO-C4X-186026)
- N-(3-Ethoxypropyl)-2-(methylamino)acetamidehydrochloride (CAS 1220038-13-0)
- 2-(propan-2-yl)-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine (CAS 1354963-17-9)
- 2-Amino-5-mercaptopyridin-3-ol (CAS 2284167-68-4)
- Methyl 3-(4-fluorophenyl)-1H-pyrazole-4-carboxylate (CAS 1017784-36-9)
- 4-Amino-2-methylquinoline-3-carboxylic acid (CAS 75353-49-0)
- Methyl 4-bromoindoline-6-carboxylate (CAS 2067333-71-3)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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