Tenofovir Impurity 68 CAS 1643116-24-8
| CAS No. | 1643116-24-8 |
| Molecular Formula | C9H14N5O4P |
| Molecular Weight | 287.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 287.21 g/mol gives Tenofovir Impurity 68 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Tenofovir Impurity 68 (CAS 1643116-24-8) is a certified pharmaceutical impurity reference standard with the molecular formula C9H14N5O4P and a molecular weight of 287.21 g/mol.
Structurally, Tenofovir Impurity 68 (C9H14N5O4P) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.5, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 287.21 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H14N5O4P |
| Molecular Weight | 287.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 5 |
Related Tenofovir Standards
- rac-Tenofovir (CAS 2667563-23-5)
- Tenofovir disoproxil Impurity 105 (CAS 2361988-22-7)
- Tenofovir disoproxil Impurity 120 (CAS 1878175-75-7)
- Tenofovir (CAS 147127-20-6)
- Tenofovir Disoproxil Impurity 26 (CAS 147127-19-3)
- Tenofovir Disoproxil Impurity 30 (CAS CATO-C4X-107630)
- Tenofovir-d (CAS 1217720-14-3)
- rac Tenofovir-d6 (CAS 1020719-94-1)
Recommended Standards
- Ethyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate (CAS 1022112-32-8)
- Adenosine Impurity 27 (CAS 103828-77-9)
- 1-((2-Bromophenyl)thio)-3,3-dimethylbutan-2-one (CAS 1152622-42-8)
- 1-(3-Bromophenyl)-2-(tert-butylthio)ethan-1-one (CAS 1152625-72-3)
- Vildagliptin Impurity 105 (CAS CATO-C4X-1100105)
- Bisoprolol Impurity 102 (CAS CATO-C4X-1247102)
- Lenvatinib Impurity 64 (CAS 2174956-62-6)
- 1-Methoxy-1H-imidazo[1,2-b]pyrazol-7-amine (CAS 943126-81-6)
- BMS 182874 Hydrochloride (CAS 1215703-04-0)
- 3-methyl-2-(propan-2-yl)butan-1-ol (CAS 18593-92-5)
- 1,3-Bis(4-cyanophenyl)thiourea (CAS 3460-58-0)
- (S,E)-4-(2-Cyclopropylvinyl)-5,6-difluoro-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one (CAS 214287-98-6)
- H-His-pNA (CAS 70324-65-1)
- D-β-Asp9-Tirzepatide (CAS CATO-CPTD788932)
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