5-Amino-1-(4-nitrophenyl)-1h-pyrazole-4-carboxylic acid CAS 16459-38-4
| CAS No. | 16459-38-4 |
| Molecular Formula | C10H8N4O4 |
| Molecular Weight | 248.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
5-Amino-1-(4-nitrophenyl)-1h-pyrazole-4-carboxylic acid (CAS 16459-38-4), molecular formula C10H8N4O4 and molecular weight 248.19 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 5-Amino-1-(4-nitrophenyl)-1h-pyrazole-4-carboxylic acid (C10H8N4O4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 248.19 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H8N4O4 |
| Molecular Weight | 248.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 4 |
Related Amino Standards
- 5-Amino-3-(3-nitrophenyl)isoxazole-4-carboxamide (CAS 15783-71-8)
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- 3-{[2-amino-4-(trifluoromethyl)phenyl]amino}propanoic acid (CAS 106484-66-6)
- 2-Amino-N-(2-(trifluoromethoxy)phenyl)propanamide (CAS 1583176-92-4)
- Ethyl 3-amino-6-(trifluoromethyl)pyridine-2-acetate (CAS 1805591-32-5)
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Recommended Standards
- Methyl 2-(5-Nitro-3-indolyl)-2-oxoacetate (CAS 163160-57-4)
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- Methyl 4-hydroxy-8-nitroquinoline-2-carboxylate (CAS 16134-01-3)
- 5-Nitro-2-(m-tolyl)-2H-1,2,3-triazole-4-carboxylic acid (CAS 1707582-65-7)
- Methyl 2-(3-cyanophenyl)-2-hydroxyacetate (CAS 52798-35-3)
- 3-Acetyl-4-methyl-1H-pyrrole-2-carbaldehyde (CAS 124815-00-5)
- Ethyl 4,5-dimethoxy-2-nitrobenzoate (CAS 100905-33-7)
- (R)-1-(5-fluoro-2-methoxyphenyl)propan-2-ol (CAS 1188412-31-8)
- Methyl 2-((1R,3R)-3-amino-1-hydroxy-4-methylpentyl)thiazole-4-carboxylate hydrochloride (CAS 921927-91-5)
- 3-Bromo-3-(2-thiomethylphenyl)propiophenone (CAS 898754-54-6)
- 1-(2-Chlorophenyl)-1H-imidazole-5-carboxylic acid (CAS 893615-79-7)
- Afatinib Impurity 5 (CAS 2223677-62-9)
- (3S)-3-hydroxycyclopentan-1-one (CAS 109905-54-6)
- Semaglutide impurity 269 (CAS CATO-C4X-2226269)
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