Afatinib Impurity 5 CAS 2223677-62-9
| CAS No. | 2223677-62-9 |
| Molecular Formula | C24H25F2N5O3 |
| Molecular Weight | 469.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Afatinib Impurity 5 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Afatinib Impurity 5 (CAS 2223677-62-9, C24H25F2N5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Afatinib Impurity 5 (C24H25F2N5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H25F2N5O3 |
| Molecular Weight | 469.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
Recommended Standards
- 6-Chloro-N4-(2-ethoxyphenyl)pyrimidine-2,4-diamine (CAS 93003-22-6)
- 4-([2,2':6',2''-Terpyridin]-4'-yl)benzene-1,3-disulfonic acid (CAS 1458013-19-8)
- 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-carboxyethyl)heptanedioic acid (CAS 798576-99-5)
- Rhizocarpic Acid (CAS 18463-11-1)
- Brivaracetam Impurity 42 (CAS 2101641-92-1)
- Baloxavir Marboxil Impurity 176 (CAS CATO-C4X-2108176)
- Tiapride impurity 8 (CAS CATO-C4X-23008)
- 1-(2-Phenyl-4-tosyloxazol-5-yl)piperidine-4-carboxamide (CAS 823829-00-1)
- Methyl 2-(2-acetamidophenyl)acetate (CAS 134810-89-2)
- Benidipine Impurity 28(Mixture of Diastereomers) (CAS 121138-43-0)
- (4-Amino-2,6-dinitrophenyl)methanolDISCONTINUED (CAS 226711-12-2)
- rel-1-(tert-Butyl) 2-methyl (2R,5R)-5-aminopiperidine-1,2-dicarboxylate (CAS 869564-38-5)
- (3-Methoxyphenyl)(1-methyl-1H-pyrrol-2-yl)methanol (CAS 944658-22-4)
- Gastric Inhibitory Polypeptide (1-30) amide (porcine) (CAS 134846-93-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com