Ethyl 2-Chloroquinoline-3-carboxylate CAS 16498-86-5
| CAS No. | 16498-86-5 |
| Molecular Formula | C12H10ClNO2 |
| Molecular Weight | 235.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 2-Chloroquinoline-3-carboxylate.
CATO supplies Ethyl 2-Chloroquinoline-3-carboxylate (CAS 16498-86-5), a certified reference material (molecular formula C12H10ClNO2, MW 235.67 g/mol) for analytical method development and quality control.
Structurally, Ethyl 2-Chloroquinoline-3-carboxylate (C12H10ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 235.67 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10ClNO2 |
| Molecular Weight | 235.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 7-chloroquinoline-2-carboxylate (CAS 116529-90-9)
- Ethyl 5-chloroquinoline-4-carboxylate (CAS 116557-07-4)
- Ethyl 7-Chloroquinoline-3-carboxylate (CAS 133455-49-9)
- Ethyl 4-Chloroquinoline-3-carboxylate (CAS 13720-94-0)
- ethyl 3-chloroquinoline-6-carboxylate (CAS 1378260-98-0)
- Ethyl 4-chloroquinoline-6-carboxylate (CAS 148018-34-2)
- Ethyl 5-chloroquinoline-6-carboxylate (CAS 180421-62-9)
- Ethyl 5-chloroquinoline-8-carboxylate (CAS 1823225-93-9)
Recommended Standards
- 2-ethyl-1-oxo-isoquinoline-5-carbonyl chloride (CAS 161427-79-8)
- 4-Chloro-5-(methylamino)-2-phenylpyridazin-3(2H)-one (CAS 1698-62-0)
- Methyl 2-(2-chloroquinolin-4-yl)acetate (CAS 158265-19-1)
- 1-(3-(4-Chlorophenyl)-5-methylisoxazol-4-yl)ethan-1-one (CAS 169814-48-6)
- 5-Methyl-2-(pyrrolidin-1-yl)pyridine (CAS 325460-82-0)
- 2-(Azulen-2-yl)furan (CAS 654075-85-1)
- 2-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine (CAS 1030420-77-9)
- Ethyl 4-(butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate hydrochloride (CAS 1135210-68-2)
- Ezetimibe Impurity 22 (CAS 190595-66-5)
- (2,4-Dichloro-6-fluorophenyl)(methyl)sulfane (CAS 1806277-16-6)
- Methyl 7-bromo-4-oxo-1,4-dihydroquinoline-6-carboxylate (CAS 2367005-12-5)
- Netupitant Impurity 6 (CAS CATO-C4X-12236)
- Sodium Fusidate Impurity 21 (CAS CATO-C4X-119721)
- Exenatide (CAS 141758-74-9)
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