Ethyl 5-chloroquinoline-6-carboxylate CAS 180421-62-9
| CAS No. | 180421-62-9 |
| Molecular Formula | C12H10ClNO2 |
| Molecular Weight | 235.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 5-chloroquinoline-6-carboxylate (C12H10ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Ethyl 5-chloroquinoline-6-carboxylate (CAS 180421-62-9), molecular formula C12H10ClNO2 and molecular weight 235.67 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10ClNO2 |
| Molecular Weight | 235.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 7-chloroquinoline-2-carboxylate (CAS 116529-90-9)
- Ethyl 5-chloroquinoline-4-carboxylate (CAS 116557-07-4)
- Ethyl 7-Chloroquinoline-3-carboxylate (CAS 133455-49-9)
- Ethyl 4-Chloroquinoline-3-carboxylate (CAS 13720-94-0)
- ethyl 3-chloroquinoline-6-carboxylate (CAS 1378260-98-0)
- Ethyl 4-chloroquinoline-6-carboxylate (CAS 148018-34-2)
- Ethyl 2-Chloroquinoline-3-carboxylate (CAS 16498-86-5)
- Ethyl 5-chloroquinoline-8-carboxylate (CAS 1823225-93-9)
Recommended Standards
- 4-Chloro-2-(6-methoxypyrimidin-4-yl)aniline (CAS 1802434-18-9)
- methyl 5-(3-chlorophenyl)-1H-pyrrole-2-carboxylate (CAS 1797395-69-7)
- Ethyl 5-chloroisoquinoline-3-carboxylate (CAS 1823315-19-0)
- 2-(2-Chloro-8-methylquinolin-3-yl)acetic acid (CAS 1710344-22-1)
- 3-(2,3-Dichlorobenzoyl)-propionic Acid (CAS 32003-41-1)
- Methyl (2E)-pent-2-enoate (CAS 15790-88-2)
- (S)-(+)-Ketoprofen-d3 Trimethamine Salt (CAS CATO-C4X-147170)
- 1-((5-Bromopyrimidin-2-yl)(methyl)amino)propan-2-ol (CAS 1272127-66-8)
- 2-Hydroxy-N1,N1-dimethylisophthalamide (CAS 1243354-57-5)
- [1,1':4',1''-Terphenyl]-3,3'',5,5''-tetracarboxylic acid (CAS 921619-89-8)
- N-(4-Chloro-2-methyl-3-(trifluoromethyl)phenyl)pivalamide (CAS 112641-23-3)
- 6-(trifluoromethyl)morpholin-3-one (CAS 1354953-95-9)
- 8-Fluoroquinoline-6-carboxylic acid (CAS 1061650-25-6)
- (Des-His1,Glu?)-Glucagon (1-29) amide (human, rat, porcine) (CAS 110084-95-2)
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