6-Fluoro-4-hydroxyquinazoline CAS 16499-56-2
| CAS No. | 16499-56-2 |
| Molecular Formula | C8H5FN2O |
| Molecular Weight | 164.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Fluoro-4-hydroxyquinazoline (CAS 16499-56-2), molecular formula C8H5FN2O and molecular weight 164.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Fluoro-4-hydroxyquinazoline (C8H5FN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-Fluoro-4-hydroxyquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5FN2O |
| Molecular Weight | 164.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
- 5-fluoro-1H-indazole-7-carbaldehyde (CAS 1100214-39-8)
- 7-Fluoro-1H-indazole-4-carbaldehyde (CAS 1186334-92-8)
- 6-Fluoro-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (CAS 1190310-04-3)
- 6-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (CAS 1190314-77-2)
- 7-Fluoro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde (CAS 1190315-32-2)
- 6-Fluoro-1h-pyrrolo[3,2-b]pyridine-3-carbaldehyde (CAS 1190316-09-6)
- 4-Fluoro-1H-pyrrolo[2,3-c]pyridine-3-carbaldehyde (CAS 1190320-43-4)
- 7-Fluoro-1H-pyrrolo[2,3-c]pyridine-3-carbaldehyde (CAS 1190321-14-2)
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