8-(Trifluoromethyl)quinazolin-4(3H)-one CAS 16499-59-5
| CAS No. | 16499-59-5 |
| Molecular Formula | C9H5F3N2O |
| Molecular Weight | 214.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-(Trifluoromethyl)quinazolin-4(3H)-one (CAS 16499-59-5) is a high-purity analytical reference standard with the molecular formula C9H5F3N2O and a molecular weight of 214.14 g/mol.
8-(Trifluoromethyl)quinazolin-4(3H)-one (C9H5F3N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 8-(Trifluoromethyl)quinazolin-4(3H)-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H5F3N2O |
| Molecular Weight | 214.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 7-(Trifluoromethyl)quinazolin-4-ol (CAS 16499-58-4)
- 6-(Trifluoromethyl)quinazolin-4(3H)-one (CAS 16544-67-5)
- 1-(4-(Trifluoromethoxy)phenyl)prop-2-yn-1-one (CAS 1603006-51-4)
- 5-(Trifluoromethyl)-1h-indazole-3-carbaldehyde (CAS 1782312-42-8)
- R-Lifitegrast (CAS 2271299-08-0)
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- 1-Chloro-8,9,10,11-tetrahydro-7H-cyclohepta[3,4]pyrazolo[1,5-a]pyrazine (CAS 1707735-01-0)
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- (R)-3-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carboxamido)propanoic acid (CAS 167308-62-5)
- 6-Bromo-7-(methoxymethyl)imidazo[1,2-a]pyridine (CAS 2791313-90-9)
- Methyl 6-cyano-1-(pentan-3-yl)-1H-indole-4-carboxylate (CAS 2444009-48-5)
- (Tyr?)-C-Peptide (dog) (CAS 101135-67-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com