4-chloro-5-fluoroquinazoline CAS 16499-60-8
| CAS No. | 16499-60-8 |
| Molecular Formula | C8H14ClFN2 |
| Molecular Weight | 192.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 4-chloro-5-fluoroquinazoline (CAS 16499-60-8), a certified reference material (molecular formula C8H14ClFN2, MW 192.66 g/mol) for analytical method development and quality control.
4-chloro-5-fluoroquinazoline (C8H14ClFN2) contains a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H14ClFN2 |
| Molecular Weight | 192.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
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- 4-chloro-8-fluoroquinazoline (CAS 124429-27-2)
- 5-chloro-8-fluoro-1,6-naphthyridine (CAS 1374652-06-8)
- 2-chloro-5-fluoro-quinazoline (CAS 1388028-12-3)
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Recommended Standards
- (2E)-3-(5-chlorothiophen-3-yl)prop-2-enoic acid (CAS 75754-89-1)
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- 4-chloro-2-methyl-5-(1-methylhydrazin-1-yl)-2,3-dihydropyridazin-3-one (CAS 96017-23-1)
- 2-(((2-Chlorothiazol-5-yl)methyl)amino)ethanol (CAS 1269145-75-6)
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- Methyl 4-(2-thiocyanatoacetamido)benzoate (CAS 1798723-08-6)
- Isoindoline-5-carbonitrile (CAS 263888-58-0)
- 3-(3,4-Dichlorophenyl)-4-iodo-1H-pyrazole (CAS 1339845-31-6)
- 3-Methylisoquinolin-8-amine (CAS 80066-65-5)
- N-(2-((Trimethylsilyl)oxy)pyrimidin-4-yl)acetamide (CAS 54230-57-8)
- Methyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylate (CAS 75092-26-1)
- 2-((4-Amino-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-benzylacetamide (CAS 869068-51-9)
- (Asp28)-Exenatide trifluoroacetate salt (CAS 1678417-24-7)
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