Posaconazole Impurity 66 CAS 165115-83-3
| CAS No. | 165115-83-3 |
| Molecular Formula | C21H21F2N3O2 |
| Molecular Weight | 385.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Posaconazole Impurity 66 (CAS 165115-83-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H21F2N3O2 and a molecular weight of 385.41 g/mol.
Based on its molecular formula C21H21F2N3O2, Posaconazole Impurity 66 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 385.41 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H21F2N3O2 |
| Molecular Weight | 385.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Posaconazole Standards
- Posaconazole impurity 248 (CAS CATO-C4X-1208248)
- Posaconazole Impurity 72 (CAS CATO-C4X-120872)
- Posaconazole Impurity 73 (CAS CATO-C4X-120873)
- Posaconazole Impurity 135 (CAS CATO-C4X-1208135)
- Posaconazole Impurity 56 (CAS 184177-81-9)
- Posaconazole Impurity 59 (CAS CATO-C4X-120859)
- Posaconazole Impurity 131 (CAS CATO-C4X-1208131)
- Posaconazole impurity 229 (CAS CATO-C4X-1208229)
Recommended Standards
- 2-(((9H-Fluoren-9-yl)methoxy)carbonyl)isoindoline-5-carboxylic acid (CAS 1564677-76-4)
- Ethyl 8-cyano-2-((4-fluorophenylthio)methyl)-7-methoxyimidazo[1,2-a]pyridine-3-carboxylate (CAS 1704066-57-8)
- N-(3,4-dimethoxybenzyl)-6,7,8-trimethoxyquinazolin-4-amine (CAS 150450-19-4)
- trans,cis-Nepetalactone (CAS 17257-15-7)
- Linaclotide Impurity 28 (CAS CATO-C4X-210628)
- Somatostatin Impurity 22 (CAS CATO-C4X-235022)
- Cefoperazone Impurity 17 (CAS CATO-C4X-114917)
- 5,6-Diethoxyindoline (CAS 1182792-37-5)
- (3,4-Difluorophenyl)(3-(morpholinomethyl)phenyl)methanone (CAS 898792-30-8)
- 5-(Methylsulfonyl)-4-phenylpyrimidin-2-amine (CAS 106073-32-9)
- 3-[(5-methylpyridin-2-yl)amino]benzoic acid (CAS 1099057-20-1)
- Methyl 5-oxazolecarboxylate (CAS 121432-12-0)
- 519-57-3 8NA53C271Z Sulochrin Benzoic acid, 2-(2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxy-, methyl ester UNII-8NA53C271Z (CAS 519-57-3)
- Insulin Glargine Metabolite M2 (CAS CATO-CPTD788867)
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