3-Methoxy Loratadine CAS 165739-73-1
| CAS No. | 165739-73-1 |
| Molecular Formula | C23H25ClN2O3 |
| Molecular Weight | 412.91 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 412.91 g/mol gives 3-Methoxy Loratadine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-Methoxy Loratadine (CAS 165739-73-1) is a high-purity analytical reference standard with the molecular formula C23H25ClN2O3 and a molecular weight of 412.91 g/mol.
Structurally, 3-Methoxy Loratadine (C23H25ClN2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 412.91 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H25ClN2O3 |
| Molecular Weight | 412.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 7-(Benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine (CAS 1197196-50-1)
- 1-Chloro-9,10-bis(phenylethynyl)anthracene (CAS 41105-35-5)
- (R)-Amlodipine-d4 (CAS 1346616-97-4)
- 2-Chloro-9,10-bis(phenylethynyl)anthracene (CAS 41105-36-6)
- 6-Chloro-N-cyclopentyl-2-methyl-5-(4-nitrophenyl)pyrimidin-4-amine (CAS 917896-23-2)
- 3,4-Dichlorothiophene (CAS 17249-76-2)
- 2-Aminobenzimidazole-4-carboxylic Acid (CAS 716362-36-6)
- N,N-dimethyl-3-(3-(pyrazin-2-yl)propyl)azetidine-3-carboxamide (CAS 1361112-34-6)
- 2-Amino-3-benzyl-5-phenylpyrazine (CAS 70217-86-6)
- 2-((3-Methylbenzyl)thio)-3-phenyl-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 685109-29-9)
- 2-[3-(pyridin-2-ylsulfanyl)propyl]-2,3-dihydro-1H-isoindole-1,3-dione (CAS 443120-58-9)
- 3-(4-Bromobenzyl)-6,8-diiodoquinazolin-4(3H)-one (CAS 302913-28-6)
- Ethyl 3-[4-(4-fluorophenyl)piperazino]-2-(methoxyimino)propanoate (CAS 478077-51-9)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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