Loratadine EP Impurity C CAS 165739-83-3
| CAS No. | 165739-83-3 |
| Molecular Formula | C22H22Cl2N2O2 |
| Molecular Weight | 417.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Loratadine EP Impurity C (CAS 165739-83-3, C22H22Cl2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Loratadine EP Impurity C (C22H22Cl2N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H22Cl2N2O2 |
| Molecular Weight | 417.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine Impurity 33 (CAS CATO-C4X-142633)
- Loratadine Impurity 52 (CAS 1432057-93-6)
- Loratadine Impurity 78 (CAS CATO-C4X-142678)
- Loratadine 2-Hydroxymethyl Impurity (USP) (CAS 609806-39-5)
- Loratadine Impurity 65 (CAS CATO-C4X-142665)
- Loratadine impurity 21 (CAS CATO-C4X-142621)
- Loratadine impurity 22 (CAS CATO-C4X-142622)
- Loratadine EP Impurity 39 (CAS 609806-38-4)
Recommended Standards
- N-[3,5-Bis(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1,3-thiazole-4-carboxamide (CAS 338396-90-0)
- 4-Bromo-N,N-diethyl-2-tosylthiazole-5-carboxamide (CAS 1000576-66-8)
- 2-({[3-(ethoxycarbonyl)-4,5,6,7-tetrafluorobenzo[b]furan-2-yl]methyl}sulphinyl)pyridinium-1-olate (CAS 256425-31-7)
- Bis(pyridin-4-ylmethyl) 4-(trifluoromethyl)pyridine-2,6-dicarboxylate (CAS 1209318-27-3)
- Emtricitabine impurity 46 (CAS CATO-C4X-123246)
- Rosuvastatin Impurity 42 (CAS 851443-04-4)
- Posaconazole Impurity 136 (CAS CATO-C4X-1208136)
- Methyl 5-(4-amino-2,5-dimethylphenoxy)-2,2-dimethylpentanoate (CAS 147686-70-2)
- 201212-33-1 (1R,3S,3aS,8bR)-3a-(2H-1,3-Benzodioxol-5-yl)-6,8-dimethoxy-3-phenyl-1,2,3,3a-tetrahydro-8bH-benzo[b]cyclopenta[d]furan-1,8b-diol DTXSID20849554 (CAS 201212-33-1)
- 4-Bromo-1-phenylpyridin-2(1H)-one (CAS 1935260-90-4)
- 5-(1,5-Dimethyl-1H-pyrazole-3-carbonyl)furan-2-carboxylic acid (CAS 1399656-54-2)
- Methyl 1-(2-(3,4-dimethylphenoxy)acetyl)-1H-indole-3-carboxylate (CAS 432532-19-9)
- 1-bromo-4-[(propan-2-ylsulfanyl)methyl]benzene (CAS 1249091-47-1)
- (10-31)Semaglutide (CAS CATO-C4X-2226283)
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