Buprenorphine EP Impurity C CAS 16614-60-1
| CAS No. | 16614-60-1 |
| Molecular Formula | C27H36N2O4 |
| Molecular Weight | 452.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Buprenorphine EP Impurity C is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Buprenorphine EP Impurity C (CAS 16614-60-1) is a certified pharmaceutical impurity reference standard with the molecular formula C27H36N2O4 and a molecular weight of 452.59 g/mol.
The molecular framework of Buprenorphine EP Impurity C (C27H36N2O4) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H36N2O4 |
| Molecular Weight | 452.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 2 |
Related Buprenorphine Standards
- Buprenorphine EP Impurity E (CAS 130668-48-3)
- 7-(S)-Buprenorphine (CAS 152610-73-6)
- Buprenorphine Related Compound A CII(Secondary Standards traceble to USP) (CAS 457071-73-7)
- Buprenorphine-D4 (CAS 136781-89-0)
- Buprenorphine Impurity 14 (CAS 16614-59-8)
- 10-Oxo Buprenorphine (CAS 1044710-08-8)
- Buprenorphine N-Oxide (CAS 112242-17-8)
- Buprenorphine 3-O-Methyl ether (CAS 16524-65-5)
Recommended Standards
- 【禁售不询】Diphenoxylate (CAS 915-30-0)
- Repaglinide EP Impurity E (CAS 147852-26-4)
- Racemic RepaglinideRacemic Repaglinide (CAS 108157-53-5)
- Octadecylphosphophosphoniumcholine (CAS 156825-89-7)
- Iobitridol Impurity 29 (CAS CATO-C4X-317829)
- Policresulen Impurity N1 (CAS 15534-74-4)
- Minocycline Impurity 26 (CAS 149934-16-7)
- 3-(4-Chlorophenyl)-1-(m-tolyl)-1H-pyrazole-5-carboxylic acid (CAS 618102-49-1)
- 2-(2-Bromoethyl)-4-fluoro-1-methylbenzene (CAS 1260913-27-6)
- 3,5-dichloro-6-methyl-1,4-oxazin-2-one (CAS 125849-94-7)
- 2-((2,3-Dihydrobenzofuran-7-yl)oxy)propan-1-amine (CAS 744977-17-1)
- 8-fluoro-6-(3,3,3-trifluoroprop-1-ynyl)-1H-quinazolin-4-one (CAS 2515616-27-8)
- 2-(3-Chloro-5-methylphenoxy)acetic acid (CAS 25141-36-0)
- Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4)
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