8-fluoro-6-(3,3,3-trifluoroprop-1-ynyl)-1H-quinazolin-4-one CAS 2515616-27-8
| CAS No. | 2515616-27-8 |
| Molecular Formula | C11H4F4N2O |
| Molecular Weight | 256.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 8-fluoro-6-(3,3,3-trifluoroprop-1-ynyl)-1H-quinazolin-4-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
8-fluoro-6-(3,3,3-trifluoroprop-1-ynyl)-1H-quinazolin-4-one (CAS 2515616-27-8), molecular formula C11H4F4N2O and molecular weight 256.16 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 8-fluoro-6-(3,3,3-trifluoroprop-1-ynyl)-1H-quinazolin-4-one is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 256.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C11H4F4N2O |
| Molecular Weight | 256.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related fluoro Standards
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- Ethyl 2-fluoro-2-phenylacetate (CAS 643-77-6)
- 2-(Aminomethylene)benzofuran-3(2H)-one (CAS 55136-19-1)
- 3-Methyl-1,2,5-thiadiazolidine 1,1-dioxide (CAS 158664-88-1)
- 4-Bromo-1-methyl-1H-indole-7-carboxylic acid (CAS 1312610-77-7)
- rac-(3aR,6aR)-hexahydro-2H-furo[2,3-c]pyrrole (CAS 1609384-28-2)
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- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
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