Rufinamide Impurity 2 CAS 166196-11-8
| CAS No. | 166196-11-8 |
| Molecular Formula | C10H7F2N3O2 |
| Molecular Weight | 239.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rufinamide Impurity 2 (CAS 166196-11-8, C10H7F2N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Rufinamide Impurity 2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 239.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Rufinamide Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7F2N3O2 |
| Molecular Weight | 239.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Rufinamide Standards
- Rufinamide-d2 (CAS 1129491-38-8)
- Rufinamide (CAS 106308-44-5)
- Rufinamide Impurity 5 (CAS 1622904-99-7)
- Rufinamide D2 Metabolite (CAS 1346597-78-1)
- Rufinamide USP Related Compound B (CAS 217448-86-7)
- Rufinamide Impurity 3 (CAS 106308-41-2)
- Rufinamide Cyano Impurity (CAS 202003-06-3)
- Rufinamide Impurity 6 (CAS 869501-51-9)
Recommended Standards
- Lenalidomide Impurity 31 (CAS 13365-26-9)
- Dimethyl 4-Nitrophthalate (CAS 610-22-0)
- Ziprasidone Impurity 77 (CAS 1455471-51-8)
- Dimethyl 5-Nitroisophthalate (CAS 13290-96-5)
- Linagliptin Impurity 25 (CAS CATO-C4X-110125)
- Crisaborole Impurity 43 (CAS 58380-11-3)
- Brexpiprazole impurity 127 (CAS CATO-C4X-1131127)
- 2-((5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(2-methyl-4-nitrophenyl)acetamide (CAS 332100-78-4)
- 2-Cyclopropoxy-5-nitrobenzaldehyde (CAS 1243327-36-7)
- 6-(Chloromethyl)-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one (CAS 1260671-02-0)
- (2-benzylphenyl)(naphthalen-2-yl)methanone 7504-44-1 KST-1A8059 (CAS 7504-44-1)
- 1,1,1-Trifluoro-3-(4-(2-hydroxyethyl)piperazin-1-yl)propan-2-ol (CAS 477847-03-3)
- (E)-4-(2-methoxyphenyl)but-3-enoic acid (CAS 127404-71-1)
- Tirzepatide Impurity 18 (CAS CATO-C4X-324018)
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