Crisaborole Impurity 43 CAS 58380-11-3
| CAS No. | 58380-11-3 |
| Molecular Formula | C7H5BrO3 |
| Molecular Weight | 217.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Crisaborole Impurity 43.
CATO supplies Crisaborole Impurity 43 (CAS 58380-11-3), a pharmacopoeial impurity reference standard (molecular formula C7H5BrO3, MW 217.02 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Crisaborole Impurity 43 (C7H5BrO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Crisaborole Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5BrO3 |
| Molecular Weight | 217.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole Impurity 6 (CAS 28547-28-6)
- Crisaborole Impurity 44 (CAS 14348-38-0)
- Crisaborole Impurity 36 (CAS 90178-72-6)
- Crisaborole Impurity 44 (CAS 90178-73-7)
- Crisaborole Impurity 6 (CAS 888967-63-3)
- Crisaborole Impurity 18 (CAS 2737-20-4)
- Crisaborole Impurity 41 (CAS 2737-19-1)
- Crisaborole Impurity 42 (CAS 1260761-47-4)
Recommended Standards
- 5-Bromosalicylic Acid (CAS 89-55-4)
- 20660-72-4 4-(bromomethyl)-3-nitroPyridine (CAS 20660-72-4)
- 3-Bromo-2-Hydroxybenzoic Acid (CAS 3883-95-2)
- Methyl 6-Bromopyridazine-3-carboxylate (CAS 65202-52-0)
- Spironolactone EP Impurity A (CAS 132458-33-4)
- Vildagliptin Impurity 18 (CAS 5001-18-3)
- Quetiapine Impurity 1 (CAS 753475-15-9)
- 2-Amino-5-[(4-chlorophenyl)methyl]-5-phenyl-4,5-dihydro-1H-imidazol-4-one (CAS 918665-07-3)
- 220445-20-5 05588G41R2 GYKI-47261 UNII-05588G41R2 Benzenamine, 4-(8-chloro-2-methyl-11H-imidazo(1,2-C)(2,3)benzodiazepin-6-yl)- (CAS 220445-20-5)
- (R)-Penbutolol Sulfate (CAS 38363-42-7)
- 3-(4-Chlorophenyl)-5-[(4-methylbenzenesulfonyl)methyl]-1,2-oxazole (CAS 478048-86-1)
- Des-(3-Oxo) 3-Amino Favipiravir (CAS 175358-03-9)
- Bisphenol A Impurity 3 (CAS 2300-15-4)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
Why CATO?
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