Clindamycin EP Impurity C CAS 16684-06-3
| CAS No. | 16684-06-3 |
| Molecular Formula | C18H33ClN2O5S |
| Molecular Weight | 424.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Clindamycin EP Impurity C (CAS 16684-06-3, C18H33ClN2O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Clindamycin EP Impurity C (C18H33ClN2O5S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H33ClN2O5S |
| Molecular Weight | 424.98 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Clindamycin Standards
- Clindamycin Impurity 149 (CAS CATO-C4X-1341149)
- Clindamycin Impurity 162 (CAS CATO-C4X-1341162)
- Clindamycin Isomer Impurity（Clindamycin EP Impurity F） (CAS 1440605-46-8)
- Clindamycin Phosphate EP Impurity E (CAS 18323-44-9)
- Clindamycin Impurity 66 (CAS CATO-C4X-134166)
- Clindamycin-13C-d3 (CAS 2140264-63-5)
- Clindamycin Impurity 5 (CAS CATO-C4X-13415)
- Clindamycin EP Impurity B (CAS 18323-43-8)
Recommended Standards
- 4-Amino-2,6-diiodobenzenesulfonic acid (CAS 3568-44-3)
- 1,2,4-Trichloro-5-[(2,4,5-trichlorophenyl)disulfanyl]benzene (CAS 3808-87-5)
- 2-Bromo-1H,1H-perfluorooct-1-ene (CAS 51249-64-0)
- 4-Bromo-2-(tert-butyl)-6-iodooxazolo[4,5-c]pyridine-7-carboxylic acid (CAS 1305325-12-5)
- Suzetrigine Impurity 49 (CAS CATO-C4X-336949)
- Sodium Cromoglicate Impurity 25 (CAS 40786-63-8)
- Beclometasone Dipropionate Monohydrate EP Impurity Q (CAS CATO-C4X-147417)
- 3-(4-Amino-2-(trifluoromethyl)phenoxy)-N,N-dimethylaniline (CAS 946697-64-9)
- 1,6-Dihydropyrrolo[2,3-b]pyrrole-2-carboxylic acid (CAS 1783528-37-9)
- (3-Nitrophenyl)-propynoic acid (CAS 321309-27-7)
- Methyl 2-(4-(benzyloxy)phenyl)-2-methylpropanoate (CAS 109492-91-3)
- Potassium trifluoro(oxetan-3-yl)borate (CAS 1430219-76-3)
- 5,7-Dimethyl-N-propylpyrazolo[1,5-a]pyrimidine-3-carboxamide (CAS 422537-29-9)
- Neuropeptide Y, human (CAS 98264-90-5)
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