Clindamycin Phosphate EP Impurity E CAS 18323-44-9
| CAS No. | 18323-44-9 |
| Molecular Formula | C18H33ClN2O5S |
| Molecular Weight | 424.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Clindamycin Phosphate EP Impurity E (CAS 18323-44-9) is a certified pharmaceutical impurity reference standard with the molecular formula C18H33ClN2O5S and a molecular weight of 424.98 g/mol.
Clindamycin Phosphate EP Impurity E (C18H33ClN2O5S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Clindamycin Phosphate EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H33ClN2O5S |
| Molecular Weight | 424.98 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Clindamycin Standards
- Clindamycin Impurity 149 (CAS CATO-C4X-1341149)
- Clindamycin Impurity 162 (CAS CATO-C4X-1341162)
- Clindamycin EP Impurity C (CAS 16684-06-3)
- Clindamycin Isomer Impurity（Clindamycin EP Impurity F） (CAS 1440605-46-8)
- Clindamycin Impurity 66 (CAS CATO-C4X-134166)
- Clindamycin-13C-d3 (CAS 2140264-63-5)
- Clindamycin Impurity 5 (CAS CATO-C4X-13415)
- Clindamycin EP Impurity B (CAS 18323-43-8)
Recommended Standards
- 1,2,4-Trichloro-5-[(2,4,5-trichlorophenyl)disulfanyl]benzene (CAS 3808-87-5)
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- 2-(Dibromomethyl)-1-nitroanthracene-9,10-dione (CAS 6941-85-1)
- Declaben (CAS 111149-90-7)
- Carboplatin Impurity 9 (CAS CATO-C4X-20619)
- Spectinomycin EP Impurity B DiHCl (CAS CATO-C4X-22167)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
- 1-Pyridin-3-yl-1-tosylmethylisocyanide (CAS 1067660-10-9)
- 2-Fluoro-3-pentafluoroethylpyridine (CAS 1713163-12-2)
- 6-Bromo-2,2-difluoro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]imidazole (CAS 188028-30-0)
- Methyl 2-(2-bromo-3,6-difluorophenyl)acetate (CAS 1805594-04-0)
- 2-Bromo-3,4,5,6-tetrafluorobenzonitrile (CAS 16583-02-1)
- 3-cyano-N-[3-(dimethylamino)propyl]benzene-1-sulfonamide (CAS 1016813-13-0)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
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