Antipyrine Impurity 1 CAS 1672-59-9
| CAS No. | 1672-59-9 |
| Molecular Formula | C13H15N3O2 |
| Molecular Weight | 245.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Antipyrine Impurity 1 (CAS 1672-59-9), a pharmacopoeial impurity reference standard (molecular formula C13H15N3O2, MW 245.28 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Antipyrine Impurity 1 (C13H15N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Antipyrine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H15N3O2 |
| Molecular Weight | 245.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 3 |
Related Antipyrine Standards
Recommended Standards
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- Resmetirom impurity 96 (CAS CATO-C4X-291296)
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- 4-Acetamidoantipyrine (CAS 83-15-8)
- Ozagrel Impurity 36 (CAS CATO-C4X-197136)
- Desloratadine Impurity 59 (CAS CATO-C4X-143059)
- Mebeverine EP Impurity N (CAS CATO-C4X-16876)
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- 3-(4-Chlorophenyl)propan-1-amine (CAS 18655-50-0)
- 2-{2-methylpyrrolo[2,1-f][1,2,4]triazin-7-yl}propan-1-amine (CAS 1551555-27-1)
- CAS CATO-C3D-262680 (CAS CATO-C3D-262680)
- 5-(2-Hydroxypyridin-3-yl)-1,2,4-oxadiazole-3-carboxylic acid (CAS 1707735-12-3)
- 2-(4-(2-Aminoethyl)piperazin-1-yl)acetic acid (CAS 87980-97-0)
- Ganirelix 1-4 peptide (CAS 208599-57-9)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com