Antipyrine Impurity 2 CAS 885-11-0
| CAS No. | 885-11-0 |
| Molecular Formula | C11H11N3O2 |
| Molecular Weight | 217.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Antipyrine Impurity 2 (C11H11N3O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Antipyrine Impurity 2 (CAS 885-11-0) is a certified pharmaceutical impurity reference standard with the molecular formula C11H11N3O2 and a molecular weight of 217.22 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11N3O2 |
| Molecular Weight | 217.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 3 |
Related Antipyrine Standards
Recommended Standards
- Pirfenidone Impurity 22 (CAS CATO-C4X-222922)
- Penicillamine Impurity 1 (CAS 856846-79-2)
- L-Alanyl-D-glutamine (CAS 281660-34-2)
- Ivacaftor Impurity 7 (CAS 52980-28-6)
- Bromhexine Impurity 48 HCl (CAS 5579-35-1)
- Bempedoic Acid Impurity 11 (CAS CATO-C4X-218911)
- Tropicamide Impurity 11 (CAS 101112-51-0)
- Minoxidil Impurity 47 (CAS 22694-45-7)
- 4,4,5,5-tetramethyl-2-[cis-2-methylcyclopropyl]-1,3,2-dioxaborolane (CAS 1309366-00-4)
- N-(2-methoxyethyl)-2-nitro-4-(trifluoromethyl)aniline (CAS 161605-63-6)
- 4-Methyl-1-(5-methylfuran-2-yl)pentane-1,3-dione (CAS 1340301-90-7)
- 5-Bromo-7-fluoro-3,4-dihydronaphthalen-2(1H)-one (CAS 1336954-16-5)
- Octadecanamide, N,N'-(iminodi-2,1-ethanediyl)bis-, polymer with 2-(chloromethyl)oxirane (CAS 26062-92-0)
- Semaglutide impurity 46 (CAS CATO-C4X-222646)
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