Butylphthalide Impurity N4 CAS 168288-19-5
| CAS No. | 168288-19-5 |
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Butylphthalide Impurity N4.
Butylphthalide Impurity N4 (CAS 168288-19-5) is a certified pharmaceutical impurity reference standard with the molecular formula C12H14O3 and a molecular weight of 206.24 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Butylphthalide Impurity N4 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 206.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
Related Butylphthalide Standards
- Butylphthalide Impurity 21 (CAS 152567-80-1)
- Butylphthalide Impurity 3 (CAS 550-37-8)
- Butylphthalide Impurity 38 (CAS 162050-43-3)
- Butylphthalide Impurity 52 (CAS 74459-23-7)
- Butylphthalide Impurity 6 (CAS 162050-42-2)
- Butylphthalide Impurity 24 (CAS 20871-32-3)
- Butylphthalide Impurity 11 (CAS 111943-62-5)
- Butylphthalide Impurity 47 (CAS 380905-48-6)
Recommended Standards
- Methyl 4-methoxy-2,3-dihydro-1H-indene-2-carboxylate (CAS 163456-61-9)
- 4-(2,4-Dimethoxyphenyl)but-3-en-2-one (CAS 16831-05-3)
- Methyl 2-(isochroman-1-yl)acetate (CAS 163277-63-2)
- (E)-Ethyl 3-(benzyloxy)acrylate (CAS 168846-45-5)
- Alectinib Impurity 5 (CAS 1247119-83-0)
- Ethacridine Lactate Impurity 15 (CAS 74859-51-1)
- Momelotinib impurity 12 (CAS 97604-14-3)
- 1-((4-Methoxyphenyl)amino)cyclohexane-1-carbonitrile (CAS 70441-14-4)
- 4-(2-Methyl-piperidin-1-yl)-phenylamine (CAS 78335-25-8)
- 6-Methylisoquinoline 6-Isopropyl-3-formylindole 6-Isopropylindole-3-carboxaldehyde 6-(1-Methylethyl)-1H-indole-3-carboxaldehyde 42398-73-2 (CAS 42398-73-2)
- (S)-5-(N-(2-Amino-2-oxoethyl)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)pentanoic acid (CAS 801240-82-4)
- (1H-Pyrrol-2-yl)methanol (CAS 27472-36-2)
- 2-((3-Oxo-2,3-dihydrobenzofuran-6-yl)oxy)propanoic acid (CAS 885532-04-7)
- Autoinducing Peptide I trifluoroacetate salt (CAS 200010-29-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com