Atropine EP Impurity B CAS 16839-98-8
| CAS No. | 16839-98-8 |
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Atropine EP Impurity B.
As a process- or degradation-related impurity, Atropine EP Impurity B (CAS 16839-98-8, C16H21NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H21NO3, Atropine EP Impurity B contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 275.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atropine EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 1 |
Related Atropine Standards
- Atropine EP Impurity A (CAS 500-55-0)
- Atropine Impurity 23 (CAS 22226-37-5)
- Atropine Impurity 44 (CAS 109496-01-7)
- Atropine Impurity 54 (CAS CATO-C4X-148954)
- Atropine EP Impurity G ((R)-Isomer) ((R)-(-)-Littorine) (CAS 21956-47-8)
- Atropine Impurity 37 (CAS 35721-90-5)
- Atropine Impurity 42 (CAS 13269-35-7)
- Atropine Impurity 60 (CAS 5627-14-5)
Recommended Standards
- Benidipine Impurity 14 (CAS 85387-34-4)
- Propranolol Impurity 39 (CAS CATO-C4X-151939)
- Pitavastatin Impurity 79 (CAS 2153433-73-7)
- Verapamil Impurity 20 (CAS 27339-25-9)
- Brexpiprazole impurity 126 (CAS CATO-C4X-1131126)
- Ivabradine Impurity 53 (CAS CATO-C4X-111953)
- Formoterol Impurity 69 (CAS 100865-09-6)
- 2-(2-(Trifluoromethyl)phenyl)isonicotinic acid (CAS 1226367-06-1)
- (E)-3-(2-(trifluoromethyl)phenyl)acrylic acid (CAS 98386-81-3)
- 4-Bromo-2-fluoro-5-nitrophenol (CAS 661463-12-3)
- 2-amino-2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol (CAS 1183772-33-9)
- (S)-2-Amino-6-methylheptane (CAS 70419-10-2)
- 6-Bromo-1-(2,4-dimethylphenyl)-2H-isoindole (CAS 358641-85-7)
- Semaglutide impurity 70 (CAS CATO-C4X-222670)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com