1-(4-Methoxyphenyl)-1-ethanone N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazone CAS 1686128-01-7
| CAS No. | 1686128-01-7 |
| Molecular Formula | C18H16ClN3OS |
| Molecular Weight | 357.86 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(4-Methoxyphenyl)-1-ethanone N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazone is closely related to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(4-Methoxyphenyl)-1-ethanone N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazone (CAS 1686128-01-7), molecular formula C18H16ClN3OS and molecular weight 357.86 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(4-Methoxyphenyl)-1-ethanone N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazone (C18H16ClN3OS) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H16ClN3OS |
| Molecular Weight | 357.86 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Methoxyphenyl Standards
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- N-(3-Methoxyphenyl)-2-((3-phenyl-1,2,4-thiadiazol-5-yl)thio)acetamide (CAS 864856-11-1)
- (2Z)-3-(2-Methoxyphenyl)-N-[(4-methylphenyl)methyl]-2-phenylprop-2-enamide (CAS 478064-13-0)
- (E)-1-(3-((4-Methoxyphenyl)sulfonyl)azetidin-1-yl)-3-phenylprop-2-en-1-one (CAS 1798423-12-7)
- 2-(4-Methoxyphenyl)-5-(pyridin-4-yl)-1,10b-dihydro-5H-benzo[e]pyrazolo[1,5-c][1,3]oxazine (CAS 303060-83-5)
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Recommended Standards
- (E)-3-(5-Chlorothiophen-2-yl)-2-(4-phenylpiperazine-1-carbonyl)acrylonitrile (CAS 1164466-58-3)
- 4-(4-Chlorophenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (CAS 182170-95-2)
- Haloperidol Impurity 39 (CAS 52669-92-8)
- (4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(4-chlorophenyl)methanone (CAS 309290-28-6)
- 2-(4-Fluorophenyl)-3-thioxohexahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-1-one (CAS 58744-68-6)
- 2-(5-Fluoropyridin-3-yl)acetaldehyde (CAS 1248701-21-4)
- Methyl 3-methoxypyridine-4-carboxylate (CAS 59786-32-2)
- 3,4-Dichloro-2H-chromen-2-one (CAS 5117-56-6)
- N-(4-(3-(4-Fluorophenyl)ureido)cyclohexyl)benzamide (CAS 1956318-69-6)
- 4-Methyl-3-(1-pyrrolidinylsulfonyl)benzoic acid (CAS 517881-18-4)
- (Z)-4-(3-Carboxyacrylamido)-2-hydroxybenzoic acid (CAS 58174-50-8)
- 5-Iodo-2-fluoro-(1,1,2,2,2-pentafluoroethyl)-benzene (CAS 1447671-87-5)
- 5-oxaspiro[2.5]octan-4-one (CAS 22566-31-0)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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