Haloperidol Impurity 39 CAS 52669-92-8
| CAS No. | 52669-92-8 |
| Molecular Formula | C21H21ClFNO |
| Molecular Weight | 357.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Haloperidol Impurity 39 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Haloperidol Impurity 39 (CAS 52669-92-8, C21H21ClFNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H21ClFNO, Haloperidol Impurity 39 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 357.85 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Haloperidol Impurity 39 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H21ClFNO |
| Molecular Weight | 357.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Haloperidol Standards
- Haloperidol Impurity 20 (CAS 185626-66-8)
- Haloperidol Impurity 22 (CAS 660844-75-7)
- Haloperidol pyridinium Chloride Impurity (CAS 125785-69-5)
- Haloperidol EP Impurity A (CAS 3109-12-4)
- Haloperidol EP Impurity B (CAS 1391052-53-1)
- Haloperidol (CAS 52-86-8)
- Haloperidol Impurity 15 (CAS CATO-C4X-146115)
- Haloperidol-d4 (CAS 1189986-59-1)
Recommended Standards
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- Valsartan Impurity 62 (CAS 1314799-75-1)
- Neobavaisoflavone (CAS 41060-15-5)
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- 1-[3-(2-chloroethyl)phenyl]octan-1-one (CAS 841251-39-6)
- Sikokianin A (CAS 106293-99-6)
- Aziridin-1-yldiphenylphosphine oxide (CAS 14839-78-2)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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