4,6-Bis(4-fluorophenyl)pyrimidine CAS 168915-00-2
| CAS No. | 168915-00-2 |
| Molecular Formula | C16H10F2N2 |
| Molecular Weight | 268.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4,6-Bis(4-fluorophenyl)pyrimidine (CAS 168915-00-2), molecular formula C16H10F2N2 and molecular weight 268.26 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, 4,6-Bis(4-fluorophenyl)pyrimidine is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 268.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,6-Bis(4-fluorophenyl)pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H10F2N2 |
| Molecular Weight | 268.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Bis Standards
- 5-{[(4-Fluorophenyl)sulfinyl]methyl}-2-furoic acid (CAS 1172368-15-8)
- 4,6-Bis(2-fluorophenyl)pyrimidine (CAS 1214330-00-3)
- 4,6-Bis(3-fluorophenyl)pyrimidine (CAS 1214358-81-2)
- 5-(((4-Fluorophenyl)thio)methyl)-N-hydroxyisoxazole-3-carboxamide (CAS 823220-13-9)
- 2-({[(4-fluorophenyl)methyl]carbamoyl}amino)-3-methylbutanoic acid (CAS 1396964-39-8)
- 2-({[(4-fluorophenyl)methyl]carbamoyl}amino)pentanoic acid (CAS 1396965-10-8)
- 2'-(2-Fluorophenyl)-2,4-dihydrospiro[1-benzopyran-3,1'-cyclopropane]-4-one (CAS 477864-18-9)
- 4-(4-Fluorophenyl)-1-methyl-3-(pyridin-2-yl)-1h-pyrazol-5-amine (CAS 1174306-33-2)
Recommended Standards
- 3-(Benzo[d][1,3]dioxol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (CAS 16669-99-1)
- 4'-Carboxybenzo-12-crown-4 (CAS 170031-43-3)
- 4-Benzoyl-3-hydroxyphenyl acrylate (CAS 15419-94-0)
- (5-Hydroxybenzofuran-3-yl)(4-methoxyphenyl)methanone (CAS 17249-65-9)
- 5-(Ethoxycarbonyl)benzo[c][1,2,5]oxadiazole 1-oxide (CAS 17348-71-9)
- 1-(2-Cyanophenyl)-N-(2-methylpropyl)methanesulfonamide (CAS 1040025-41-9)
- 7-Ethyl-5-mercapto-1,3-dimethylpyrimido[4,5-{d}]pyrimidine-2,4(1{H},3{H})-dione (CAS 926202-85-9)
- Calcifediol Monohydrate EP Impurity A (CAS 61585-29-3)
- Methyl 6-chloro-1,2,3,4-tetrahydroquinoline-8-carboxylate (CAS 1823887-92-8)
- 6-chloro-3,5-diazatricyclo[6.2.2.0²,⁷]dodeca-2,4,6-triene (CAS 2306275-71-6)
- 2-(3-Bromo-4-cyano-2-fluorophenyl)acetic acid (CAS 1806061-82-4)
- 5-Bromo-3,4-dihydro-2H-pyran (CAS 26274-19-1)
- 3-Chloro-4-[(6-methyl-3-pyridyl)oxy]aniline (CAS 848482-82-6)
- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
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