Methyl 2-amino-3,4-difluorobenzoate CAS 170108-07-3
| CAS No. | 170108-07-3 |
| Molecular Formula | C8H7F2NO2 |
| Molecular Weight | 187.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 2-amino-3,4-difluorobenzoate.
CATO supplies Methyl 2-amino-3,4-difluorobenzoate (CAS 170108-07-3), a certified reference material (molecular formula C8H7F2NO2, MW 187.14 g/mol) for analytical method development and quality control.
The molecular framework of Methyl 2-amino-3,4-difluorobenzoate (C8H7F2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7F2NO2 |
| Molecular Weight | 187.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- Methyl 6-amino-2,3-difluorobenzoate (CAS 1029421-95-1)
- (S)-2-Amino-2-(2,3-difluorophenyl)acetic acid (CAS 1043500-35-1)
- Methyl 4-Amino-3,5-difluorobenzoate (CAS 1162676-00-7)
- Methyl 2-amino-3,6-difluorobenzoate (CAS 1184204-30-5)
- Methyl 2-amino-3,5-difluorobenzoate (CAS 1184559-12-3)
- Methyl 3-amino-2,5-difluorobenzoate (CAS 1186194-15-9)
- Methyl 5-amino-2,3-difluorobenzoate (CAS 1227269-02-4)
- (R)-2-Amino-2-(2,5-difluorophenyl)acetic acid (CAS 1228556-65-7)
Recommended Standards
- 2-(2,2-Difluoroethoxy)nicotinaldehyde (CAS 1698780-65-2)
- 2-(Difluoromethyl)-6-methylnicotinic acid (CAS 1708178-67-9)
- 4-Amino-2,3-difluorophenyl acetate (CAS 162819-06-9)
- Methyl 3-amino-2,4-difluorobenzoate (CAS 1780871-49-9)
- 1-(Chloromethoxy)-2-fluorobenzene (CAS 1394288-17-5)
- 2-(1-{[(9H-fluoren-9-yl)methoxy]carbonyl}azetidin-3-yl)propanoic acid (CAS 1594944-87-2)
- Ethyl 4-chlorothiazole-5-carboxylate (CAS 444909-55-1)
- (1S,4S)-Benzyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (CAS 845866-59-3)
- Cyclobutylmethyl 3-piperidinylmethyl etherhydrochloride (CAS 1211505-35-9)
- (2R,3R,4S,5S)-2-((benzoyloxy)methyl)-5-fluorotetrahydrofuran-3,4-diyl dibenzoate (CAS 6301-48-0)
- 6-({[(tert-butoxy)carbonyl]amino}methyl)imidazo[1,2-a]pyridine-2-carboxylic acid (CAS 1038916-43-6)
- Ethyl 3-bromo-5-chloro-2-hydroxybenzoate (CAS 773134-85-3)
- 3-(1H-pyrazol-1-yl)pentanenitrile (CAS 1152915-18-8)
- Ginseng Tetrapeptide (CAS 178553-95-2)
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