Voriconazole Impurity 27 CAS 1702684-04-5
| CAS No. | 1702684-04-5 |
| Molecular Formula | C6H6BrFN2 |
| Molecular Weight | 205.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Voriconazole Impurity 27 (CAS 1702684-04-5, C6H6BrFN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Voriconazole Impurity 27 (C6H6BrFN2) is characterized by a nitrile group, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Voriconazole Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6BrFN2 |
| Molecular Weight | 205.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Voriconazole Standards
- Voriconazole Impurity 80 (CAS 188416-47-9)
- Voriconazole Impurity 95 (CAS 7072-23-3)
- Voriconazole Impurity 65 (CAS 3741-24-0)
- Voriconazole Impurity 77 (CAS 137234-85-6)
- Voriconazole Impurity 71 (CAS 1359667-92-7)
- Voriconazole Impurity 60 (CAS 116622-90-3)
- Voriconazole Impurity 59 (CAS 141060-00-6)
- Voriconazole Impurity N1 (CAS 929249-84-3)
Recommended Standards
- 6-Bromo-5-fluoro-3-methyl-pyridin-2-amine (CAS 2086189-45-7)
- 6-Bromo-3-fluoro-4-methylpyridin-2-amine (CAS 2803281-44-7)
- 3,5-Dichloro-2-methyl-benzoic acid (CAS 101567-48-0)
- 5-Bromo-3-fluorobenzene-1,2-diamine (CAS 517920-69-3)
- Cyclophosphamide Impurity 4 (CAS 2810251-24-0)
- Mirogabalin Impurity N10 (CAS 188398-87-0)
- Hydrocortisone impurity 39 (Triethylamine Salt) (CAS CATO-C4X-140139)
- 5-Cyclopentyl-1H-pyrazole-4-carboxylic acid (CAS 1250341-33-3)
- 3-Bromo-7-chloro-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidine (CAS 885720-87-6)
- Lifitegrast Impurity 79 (CAS CATO-C4X-240979)
- 1,2-O-Dioctadecyl-rac-glycerol (CAS 13071-61-9)
- Tamsulosin Impurity 19 (CAS 116091-63-5)
- 2-(Methoxyamino)propanoic acid (CAS 54837-08-0)
- HA Peptide (CAS 92000-76-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com