4-((2,4-Dichlorobenzyl)oxy)-3-ethoxy-5-iodobenzonitrile CAS 1706445-44-4
| CAS No. | 1706445-44-4 |
| Molecular Formula | C16H12Cl2INO2 |
| Molecular Weight | 448.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-((2,4-Dichlorobenzyl)oxy)-3-ethoxy-5-iodobenzonitrile (CAS 1706445-44-4), molecular formula C16H12Cl2INO2 and molecular weight 448.08 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-((2,4-Dichlorobenzyl)oxy)-3-ethoxy-5-iodobenzonitrile (C16H12Cl2INO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-((2,4-Dichlorobenzyl)oxy)-3-ethoxy-5-iodobenzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl2INO2 |
| Molecular Weight | 448.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 1 |
Related Dichlorobenzyl Standards
- (E)-1-(2,4-dichlorobenzyl)-2-(2,4-dichlorostyryl)-1H-benzo[d]imidazole (CAS 338771-83-8)
- (E)-1-(2,5-dichlorobenzyl)-2-(2,4-dichlorostyryl)-1H-benzo[d]imidazole (CAS 338771-81-6)
- 2-((2-((3,4-Dichlorobenzyl)thio)-1-methyl-1H-imidazol-5-yl)methoxy)isoindoline-1,3-dione (CAS 400088-13-3)
- 3-(2,6-Dichlorobenzyl)-2-methyl-1-(4-(phenyldiazenyl)phenyl)pyridin-4(1H)-one (CAS 400088-49-5)
- 4-(5-((3,4-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)-2-phenylthiazole (CAS 338759-70-9)
- 2-((2,6-Dichlorobenzyl)thio)-4,6-diphenylnicotinonitrile (CAS 400738-16-1)
- 3-((2,6-Dichlorobenzyl)oxy)-N-(2,3-dichlorophenyl)thiophene-2-carboxamide (CAS 344270-16-2)
- 2-((2,6-Dichlorobenzyl)thio)-5-((naphthalen-1-ylmethyl)thio)-1,3,4-thiadiazole (CAS 476484-10-3)
Recommended Standards
- 3,6-Bis(5-bromo-2-pyridinyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (CAS 777079-50-2)
- 1-[(2,4-Dichlorophenyl)methoxy]-3-[(3,4-dichlorophenyl)methyl]imidazolidine-2,4,5-trione (CAS 320422-88-6)
- 2,2-Difluoro-2-(1,1,2,2-tetrafluoro-2-(perfluorobutoxy)ethoxy)acetyl fluoride (CAS 172897-75-5)
- bis(2-iodothiophen-3-yl)methanol (CAS 474416-59-6)
- Ethyl 2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5-carboxylate (CAS 937601-40-6)
- (R)-Sertaconazole-d6 (CAS 1795786-36-5)
- 2,3-Dibromobutanenitrile 2,3-Dibromobutanenitrile (90%) 25109-76-6 (CAS 25109-76-6)
- 3-Chloro-N-(2,3-dimethylphenyl)benzamide (CAS 196700-85-3)
- Ceftriaxone Impurity 17 (CAS CATO-C4X-116317)
- 4-Bromo-3-chloro-5-fluorophenacyl chloride (CAS 1806971-70-9)
- 2-[2-(2-Methoxy-4-propylphenoxy)ethyl]piperidinehydrochloride (CAS 1219982-97-4)
- Endo-Gly29-Tirzepatide (CAS CATO-CPTD788685)
- 2-bromo-N,N-dimethyl-ethanamine (CAS 5459-68-7)
- Semaglutide impurity 259 (CAS CATO-C4X-2226259)
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